Neuroanatomical abnormalities in chronic tinnitus in the human brain.
Neuroanatomical abnormalities in chronic tinnitus in the human brain.
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DOI：
10.1016/j.neubiorev.2014.05.013
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发表时间：
2014-09
影响因子：
8.2
通讯作者：
Langers, Dave R. M.
中科院分区：
文献类型：
--
作者：
Adjamian, Peyman;Hall, Deborah A.;Palmer, Alan R.;Allan, Thomas W.;Langers, Dave R. M.
我们回顾耳鸣的脑解剖学研究。我们根据这些研究的证据评估“门控机制”。我们讨论的结果和结果之间的差异的可能原因。耳鸣的症状有哪些？耳鸣的症状有哪些？我们确定了方法上的问题，并为未来的研究提出了策略。在本文中，我们回顾了研究慢性耳鸣的脑形态，以更好地了解疾病的潜在病理生理学。耳鸣是一种常见的神经系统疾病，也是一种神经系统疾病。然而，确切的机制仍然难以捉摸，也不清楚涉及哪些结构。由于大脑结构和功能是高度相关的，解剖差异的识别可能会揭示耳鸣产生和维持的机制。我们讨论了听觉皮层、边缘系统和前额叶皮层等的解剖学变化。具体而言，我们讨论了耳鸣的门控机制，并评估了支持该模型的证据，从大脑解剖学的研究。虽然个别研究声称与耳鸣相关的显着影响，但结果是不同的，甚至在研究中相互矛盾。此外，结果往往被听力损失的存在所混淆。我们的结论是，目前，结构异常具体相关耳鸣的整体证据是穷人。随着这一研究领域的不断扩大，我们确定了研究设计的一些关键因素，并提出了未来研究的策略。
We review brain anatomical studies of tinnitus. We evaluate the “gating mechanism” in light of the evidence from these studies. We discuss the results and the possible causes of disparity between findings. Overall, the evidence for structural abnormalities in tinnitus is unconvincing. We identify methodological concerns and suggest strategies for future research. In this paper, we review studies that have investigated brain morphology in chronic tinnitus in order to better understand the underlying pathophysiology of the disorder. Current consensus is that tinnitus is a disorder involving a distributed network of peripheral and central pathways in the nervous system. However, the precise mechanism remains elusive and it is unclear which structures are involved. Given that brain structure and function are highly related, identification of anatomical differences may shed light upon the mechanism of tinnitus generation and maintenance. We discuss anatomical changes in the auditory cortex, the limbic system, and prefrontal cortex, among others. Specifically, we discuss the gating mechanism of tinnitus and evaluate the evidence in support of the model from studies of brain anatomy. Although individual studies claim significant effects related to tinnitus, outcomes are divergent and even contradictory across studies. Moreover, results are often confounded by the presence of hearing loss. We conclude that, at present, the overall evidence for structural abnormalities specifically related to tinnitus is poor. As this area of research is expanding, we identify some key considerations for research design and propose strategies for future research.
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影响因子：
2.8
作者：
Aldhafeeri, Faten M.;Mackenzie, Ian;Sluming, Vanessa
通讯作者：
Sluming, Vanessa
DOI：
10.2174/1874440001004010016
发表时间：
2010-06-30
期刊：
The open neuroimaging journal
影响因子：
--
作者：
Crippa, Alessandro;Lanting, Cris P;Roerdink, Jos B T M
通讯作者：
Roerdink, Jos B T M
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
2.8
作者：
Benson, Randall R.;Gattu, Ramtilak;Cacace, Anthony T.
通讯作者：
Cacace, Anthony T.
DOI：
10.3109/01050399509042204
发表时间：
1995-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
ATTIAS, J;SHEMESH, Z;SOHMER, H
通讯作者：
SOHMER, H