Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.

Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
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DOI:
10.1053/j.gastro.2020.09.056
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发表时间:
2021-01
期刊:
影响因子:
29.4
通讯作者:
Chang EB
Chang EB
中科院分区:
医学1区
文献类型:
--
作者:
Lee M;Chang EB

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炎症性肠病(IBD)是环境、微生物、免疫和遗传因素共同作用的结果。肠道微生物群的改变与IBD的发展和进展有关,但尚不清楚哪些微生物群参与其中或它们如何导致IBD。我们回顾了影响肠道微生物群的遗传和环境因素,肠道微生物及其生物产物在IBD的发展和临床过程中的作用,以及基于微生物组的治疗可用于预防、管理和最终治愈IBD的策略。我们讨论的研究成果,有助于弥合基础科学和临床应用之间的差距。
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial, immunological, and genetic factors. Alterations in the gut microbiota have been associated with development and progression of IBD, but it is not clear which populations of microbes are involved or how they might contribute to IBD. We review the genetic and environmental factors affecting the gut microbiota, the roles of gut microbes and their bioproducts in the development and clinical course of IBD, and strategies by which microbiome-based therapies can be used to prevent, manage, and eventually cure IBD. We discuss research findings that help bridge the gap between the basic sciences and clinical application.
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