Tissue engineering of blood vessel.
Tissue engineering of blood vessel.
复制标题
血管组织工程。
DOI：
10.1111/j.1582-4934.2007.00099.x
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发表时间：
2007-09
影响因子：
5.3
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Zhang WJ;Liu W;Cui L;Cao Y
血管移植物在冠状动脉和外周搭桥手术中需求量很大。尽管已经开发了合成移植物，但是用纯合成聚合物导管替换血管常常导致这种移植物的失效，特别是在直径小于6mm的移植物中或在低血流量区域中，这主要是由于血栓形成的早期形成。此外，常用的材料缺乏生长潜力，长期结果显示了几种与材料相关的失效，如狭窄、血栓栓塞、钙沉积和感染。组织工程已成为一种很有前途的方法，用于产生具有生长潜力的生物相容性血管移植物。自温伯格和贝尔首次成功地用胶原和培养的血管细胞构建血管以来，血管工程领域取得了长足的进展。目前，组织工程化血管已在体外成功构建，并可用于动物模型血管缺损的修复。本文综述了该领域的主要进展，包括种子细胞来源、生物可降解支架材料、构建技术以及临床应用的可喜成果。还讨论了其余的挑战。
Vascular grafts are in large demand for coronary and peripheral bypass surgeries. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter or in the areas of low blood flow, mainly due to the early formation of thrombosis. Moreover, the commonly used materials lack growth potential, and long-term results have revealed several material-related failures, such as stenosis, thromboembolization, calcium deposition and infection. Tissue engineering has become a promising approach for generating a bio-compatible vessel graft with growth potential. Since the first success of constructing blood vessels with collagen and cultured vascular cells by Weinberg and Bell, there has been considerable progress in the area of vessel engineering. To date, tissue- engineered blood vessels (TEBVs) could be successfully constructed in vitro, and be used to repair the vascular defects in animal models. This review describes the major progress in the field, including the seeding cell sources, the biodegradable scaffolds, the construction technologies, as well as the encouraging achievements in clinical applications. The remaining challenges are also discussed.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
3.1
作者：
Boland, ED;Matthews, JA;Bowlin, GL
通讯作者：
Bowlin, GL
影响因子：
--
作者：
Borschel, GH;Huang, YC;Brown, DL
通讯作者：
Brown, DL
DOI：
10.1115/1.429652
发表时间：
2000-06-01
影响因子：
1.7
作者：
Girton, TS;Oegema, TR;Tranquillo, RT
通讯作者：
Tranquillo, RT
影响因子：
37.8
作者：
Griese, DP;Ehsan, A;Dzau, VJ
通讯作者：
Dzau, VJ