Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans.
Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans.
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健康人常见 OXTR 基因变异与大脑结构和默认模式网络功能的关系
DOI：
10.1016/j.neuroimage.2016.12.062
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发表时间：
2017-02-15
期刊：
影响因子：
5.7
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Wang J;Braskie MN;Hafzalla GW;Faskowitz J;McMahon KL;de Zubicaray GI;Wright MJ;Yu C;Thompson PM
大量研究表明，催产素受体（OXTR）基因多态性可能会影响与社交缺陷相关的社会行为和精神疾病，例如自闭症谱系障碍（ASD）、精神分裂症以及情绪和焦虑障碍。然而，这些关联背后的神经机制仍不清楚。与对照组相比，患有这些精神疾病的患者在大脑结构和默认模式网络 (DMN) 区域（也称为功能连接）之间的静息状态功能磁共振成像 (rs-fMRI) 信号同步性方面表现出差异。我们在 328 名健康年轻人中使用逐步成像遗传学方法来测试 OXTR 中的 10 个 SNP 与 DMN 同步性和一些相关大脑区域结构的差异相关的假设。由于 OXTR 效应可能与性别相关，因此我们还测试了我们的发现是否受性别调节。与具有 GG 基因型的个体相比，OXTR rs2254298 A 等位基因携带者在从右侧额岛皮层延伸到壳核和苍白球的簇中以及在双侧背侧前扣带皮层 (dACC) 中具有显着较低的 rsFC 和 PCC；所有观察到的效应仅在男性中发现。此外，与具有rs2254298 GG基因型的男性个体相比，男性A等位基因携带者的双侧dACC中的皮质灰质明显更薄。我们的研究结果表明，可能存在性别二态性机制，通过这种机制，OXTR 基因的自然发生的变异可能会影响与神经精神疾病有关的 DMN 相关区域的大脑结构和功能。
A large body of research suggests that oxytocin receptor (OXTR) gene polymorphisms may influence both social behaviors and psychiatric conditions related to social deficits, such as autism spectrum disorders (ASDs), schizophrenia, and mood and anxiety disorders. However, the neural mechanism underlying these associations is still unclear. Relative to controls, patients with these psychiatric conditions show differences in brain structure, and in resting state fMRI (rs-fMRI) signal synchronicity among default mode network (DMN) regions (also known as functional connectivity). We used a stepwise imaging genetics approach in 328 healthy young adults to test the hypothesis that 10 SNPs in OXTR are associated with differences in DMN synchronicity and structure of some of the associated brain regions. As OXTR effects may be sex-dependent, we also tested whether our findings were modulated by sex. OXTR rs2254298 A allele carriers had significantly lower rsFC with PCC in a cluster extending from the right fronto-insular cortex to the putamen and globus pallidus, and in bilateral dorsal anterior cingulate cortex (dACC) compared to individuals with the GG genotype; all observed effects were found only in males. Moreover, compared to the male individuals with GG genotype ofrs2254298, the male A allele carriers demonstrated significantly thinner cortical gray matter in the bilateral dACC. Our findings suggest that there may be sexually dimorphic mechanisms by which a naturally occurring variation of the OXTR gene may influence brain structure and function in DMN-related regions implicated in neuropsychiatric disorders.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
影响因子：
2.7
作者：
Di X;Biswal BB
通讯作者：
Biswal BB
影响因子：
7.6
作者：
Dodhia, Sonam;Hosanagar, Avinash;Phan, K. Luan
通讯作者：
Phan, K. Luan
影响因子：
5.7
作者：
Bzdok D;Heeger A;Langner R;Laird AR;Fox PT;Palomero-Gallagher N;Vogt BA;Zilles K;Eickhoff SB
通讯作者：
Eickhoff SB