Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 Survivors.
Adapting the UK Biobank Brain Imaging Protocol and Analysis Pipeline for the C-MORE Multi-Organ Study of COVID-19 Survivors.
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DOI：
10.3389/fneur.2021.753284
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发表时间：
2021
影响因子：
3.4
通讯作者：
Smith SM
中科院分区：
文献类型：
--
作者：
Griffanti L;Raman B;Alfaro-Almagro F;Filippini N;Cassar MP;Sheerin F;Okell TW;Kennedy McConnell FA;Chappell MA;Wang C;Arthofer C;Lange FJ;Andersson J;Mackay CE;Tunnicliffe EM;Rowland M;Neubauer S;Miller KL;Jezzard P;Smith SM
SARS-CoV-2感染已被证明会损害包括大脑在内的多个器官。多器官MRI可以进一步了解COVID-19对器官健康的影响，但需要在数据采集的丰富性和质量与总扫描时间之间取得平衡。我们调整了英国生物库脑MRI方案，以产生高质量的图像，同时适合作为covid -19后多器官MRI检查的一部分。该分析管线也改编自UK Biobank，包括旨在评估COVID-19可能影响的新的成像衍生表型（IDPs）。在参加牛津C-MORE研究的51名出院后的COVID-19患者和25名对照组中进行了该方案和管道的首次应用。该方案在17分钟内获得高分辨率T1、T2-FLAIR、扩散加权图像、敏感性加权图像和动脉自旋标记数据。自动成像管道获得1,575个IDPs，评估脑解剖（包括嗅球体积和强度）和组织灌注、高强度、扩散和易感性。在C-MORE数据中，与萎缩、小血管疾病和嗅球相关的IDPs与临床放射学报告一致。我们的探索性分析初步揭示了康复的COVID-19患者和对照组在严重程度组之间的一些组差异，但在嗅觉缺失组之间没有差异。C-MORE研究的随访成像目前正在进行中，该方案目前正在其他大规模研究中使用。协议、管道代码和数据均可公开获取，将进一步有助于了解COVID-19的中长期影响。
SARS-CoV-2 infection has been shown to damage multiple organs, including the brain. Multiorgan MRI can provide further insight on the repercussions of COVID-19 on organ health but requires a balance between richness and quality of data acquisition and total scan duration. We adapted the UK Biobank brain MRI protocol to produce high-quality images while being suitable as part of a post-COVID-19 multiorgan MRI exam. The analysis pipeline, also adapted from UK Biobank, includes new imaging-derived phenotypes (IDPs) designed to assess the possible effects of COVID-19. A first application of the protocol and pipeline was performed in 51 COVID-19 patients post-hospital discharge and 25 controls participating in the Oxford C-MORE study. The protocol acquires high resolution T1, T2-FLAIR, diffusion weighted images, susceptibility weighted images, and arterial spin labelling data in 17 min. The automated imaging pipeline derives 1,575 IDPs, assessing brain anatomy (including olfactory bulb volume and intensity) and tissue perfusion, hyperintensities, diffusivity, and susceptibility. In the C-MORE data, IDPs related to atrophy, small vessel disease and olfactory bulbs were consistent with clinical radiology reports. Our exploratory analysis tentatively revealed some group differences between recovered COVID-19 patients and controls, across severity groups, but not across anosmia groups. Follow-up imaging in the C-MORE study is currently ongoing, and this protocol is now being used in other large-scale studies. The protocol, pipeline code and data are openly available and will further contribute to the understanding of the medium to long-term effects of COVID-19.
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影响因子：
5.7
作者：
Griffanti L;Zamboni G;Khan A;Li L;Bonifacio G;Sundaresan V;Schulz UG;Kuker W;Battaglini M;Rothwell PM;Jenkinson M
通讯作者：
Jenkinson M
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
8.3
作者：
DeCarli, C;Fletcher, E;Jagust, WJ
通讯作者：
Jagust, WJ
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.3
作者：
Choi Y;Lee MK
通讯作者：
Lee MK