Fiber bundle length and cognition: a length-based tractography MRI study.
Fiber bundle length and cognition: a length-based tractography MRI study.
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DOI：
10.1007/s11682-014-9334-8
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发表时间：
2015-12
影响因子：
3.2
通讯作者：
Paul, Robert H.
中科院分区：
文献类型：
--
作者：
Behrman-Lay, Ashley M.;Usher, Christina;Conturo, Thomas E.;Correia, Stephen;Laidlaw, David H.;Lane, Elizabeth M.;Bolzenius, Jacob;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Cabeen, Ryan;Akbudak, Erbil;Luo, Xi;Yan, Peisi;Paul, Robert H.
执行功能（EF）和认知处理速度（CPS）是随着年龄增长而下降的两个认知性能领域。已知EF和CPS降低与年龄相关的额叶体积损失相关。然而，目前尚不清楚这些区域的白色物质微结构是否与年龄相关的EF和/或CPS下降有关。我们利用来自扩散张量MRI的定量纤维束成像指标来研究73名健康老年人投射到不同肺叶的平均纤维束长度（FBL）与EF/CPS性能之间的关系。我们用连线测验（TMT）、色词干扰测验、字母-数字排序（L-N Seq）和符号编码来测量EF和CPS。结果显示，顶叶和枕叶FBL解释了EF的显著差异。额叶，颞叶和枕叶FBL解释了CPS的显著差异。较短的枕骨FBL与EF测试TMT-B和CWIT 3的较差性能相关。较短的额叶、顶叶和枕叶FBL与L-N序列和符号编码的较差性能相关。较短的额叶和颞叶FBL与CPS测试TMT-A和CWIT 1的较低表现相关。FBL缩短也与年龄增加有关。结果表明，在老年人中，与EF和CPS性能较差相关的特定大脑区域中与年龄相关的FBL缩短。总的来说，结果支持额叶老化假说和处理速度理论，这表明每种机制都有助于与年龄相关的认知能力下降。
Executive function (EF) and cognitive processing speed (CPS) are two cognitive performance domains that decline with advanced age. Reduced EF and CPS are known to correlate with age-related frontal-lobe volume loss. However, it remains unclear whether white matter microstructure in these regions is associated with age-related decline in EF and/or CPS. We utilized quantitative tractography metrics derived from diffusion-tensor MRI to investigate the relationship between the mean fiber bundle lengths (FBLs) projecting to different lobes, and EF/CPS performance in 73 healthy aging adults. We measured aspects of EF and CPS with the Trail Making Test (TMT), Color-Word Interference Test, Letter-Number Sequencing (L-N Seq), and Symbol Coding. Results revealed that parietal and occipital FBLs explained a significant portion of variance in EF. Frontal, temporal and occipital FBLs explained a significant portion of variance in CPS. Shorter occipital FBLs were associated with poorer performance on the EF tests TMT-B and CWIT 3. Shorter frontal, parietal, and occipital FBLs were associated with poorer performance on L-N Seq and Symbol Coding. Shorter frontal and temporal FBLs were associated with lower performance on CPS tests TMT-A and CWIT 1. Shorter FBLs were also associated with increased age. Results suggest an age-related FBL shortening in specific brain regions related to poorer EF and CPS performance among older adults. Overall, results support both the frontal aging hypothesis and processing speed theory, suggesting that each mechanism is contributing to age-related cognitive decline.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
9.9
作者：
Baker, Laurie M.;Laidlaw, David H.;Paul, Robert H.
通讯作者：
Paul, Robert H.
影响因子：
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作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
影响因子：
9.9
作者：
Guttmann, CRG;Jolesz, FA;Albert, MS
通讯作者：
Albert, MS
影响因子：
2.9
作者：
FUSTER, JM;BAUER, RH;JERVEY, JP
通讯作者：
JERVEY, JP