Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics.
Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics.
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DOI：
10.1038/s41598-022-15837-9
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发表时间：
2022-08-25
影响因子：
4.6
通讯作者：
Schwartz, Stephen M.
中科院分区：
文献类型：
--
作者：
Yarborough, Sarah;Fitzpatrick, Annette;Schwartz, Stephen M.
犬认知功能障碍（CCD）是一种老年犬的神经退行性疾病。先前已在相对较小的犬队列中使用多种不同的评定量表进行了描述。本研究旨在使用由先前研究人员开发的最小修改的CCD评定量表，更彻底地描述参与犬老化项目（DAP）的大型全国性伴侣犬队列（n = 15，019）中CCD的患病率。采用单变量和多变量logistic回归模型和受试者工作曲线（ROC）分析，研究了各种犬特征、预测寿命四分位数和CCD之间的关联。当控制所有其他特征时，CCD的几率随着年龄的增加而增加52%。在相同年龄、健康状况、品种类型和绝育状态的狗中，不活跃的狗患CCD的几率是非常活跃的狗的6.47倍。当控制年龄、品种类型、活动水平和其他合并症时，有神经系统、眼睛或耳朵疾病史的犬患CCD的几率更高。寿命四分位数分析显示CCD阳性和阴性犬之间具有良好的区分能力。因此，基于体重的寿命四分位数估计可以作为兽医进行CCD筛查的工具。
Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales. This study aimed to use a minimally modified CCD rating scale developed by previous researchers to describe the prevalence of CCD more thoroughly in a large, nationwide cohort of companion dogs participating in the Dog Aging Project (DAP) (n = 15,019). Associations between various canine characteristics, predicted lifespan quartiles, and CCD were examined using univariable and multivariable logistic regression models and receiver operating curve (ROC) analysis. When controlling for all other characteristics, the odds of CCD increased 52% with each additional year of age. Among dogs of the same age, health status, breed type, and sterilization status, odds of CCD were 6.47 times higher in dogs who were not active compared to those who were very active. When controlling for age, breed type, activity level, and other comorbidities, dogs with a history of neurological, eye, or ear disorders had higher odds of CCD. Lifespan quartile analysis showed excellent discriminating ability between CCD positive and negative dogs. Weight-based lifespan quartile estimation could therefore serve as a tool to inform CCD screening by veterinarians.
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影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
2.2
作者：
Salvin, Hannah E.;McGreevy, Paul D.;Valenzuela, Michael J.
通讯作者：
Valenzuela, Michael J.
影响因子：
4.2
作者：
Colle, MA;Hauw, JJ;Duykaerts, C
通讯作者：
Duykaerts, C
影响因子：
39.2
作者：
Larson, EB;Wang, L;Kukull, W
通讯作者：
Kukull, W
影响因子：
1.9
作者：
Lakshminarayanan, V;Lagrave, J;Shankle, R
通讯作者：
Shankle, R