Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.
Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.
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DOI：
10.1007/s00281-007-0077-0
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发表时间：
2007-06
影响因子：
9
通讯作者：
Arck, Petra C.
中科院分区：
文献类型：
--
作者：
Tariverdian, Nadja;Theoharides, Theoharis C.;Siedentopf, Friederike;Gutierrez, Gabriela;Jeschke, Udo;Rabinovich, Gabriel A.;Blois, Sandra M.;Arck, Petra C.
子宫内膜异位症是一种慢性疾病，其特征是子宫内膜组织位于子宫腔外，影响四分之一的年轻妇女，并与慢性盆腔疼痛和不孕症有关。然而，对子宫内膜异位症的病理生理学和有效的治疗策略的深入了解仍然是难以捉摸的。不充分的免疫和神经内分泌反应显着参与子宫内膜异位症的病理生理，并在本审查的主要结果进行了总结。我们在这里讨论不同的免疫机制，特别是粘附分子，蛋白质-聚糖相互作用，促血管生成介质在疾病的发展和进展中的作用。最后，我们介绍了子宫内膜播散的概念，子宫内膜异位症的主要临床症状引起的高水平的感知压力的神经内分泌免疫失衡的结果。
Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis.
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