Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection.
Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection.
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DOI：
10.3390/pathogens11050526
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发表时间：
2022-04-29
期刊：
影响因子：
3.7
通讯作者：
Saika, Shizuya
中科院分区：
文献类型：
--
作者：
Imai, Kazuki;Sumioka, Takayoshi;Iwanishi, Hiroki;Takada, Yukihisa;Murata, Shin'ichi;Iwamoto, Ryuta;Okada, Yuka;Saika, Shizuya
背景：胶孢炭疽菌的角膜感染并不常见，通常局限于角膜前基质层。然而，我们观察到一例角膜基质穿孔造成这种真菌在一个妥协的条件。病例：一位73岁的女性因严重的角膜溃疡向我们咨询。她是一名种植橙子的农民，患有风湿性关节炎十多年。在与我们协商之前，她接受了右眼翼状胬肉切除术。然后，她出现角膜溃疡，并在诊断为类风湿性关节炎相关眼基质溃疡后接受局部糖皮质激素治疗。在我们的第一次会诊中，在她的右角膜的颞下区域观察到角膜溃疡。生物学检查检测到一种丝状真菌，胶孢炭疽菌。局部和全身抗真菌治疗没有显着效果。会诊后14天，病变恶化，导致基质穿孔，使用保存的角膜纽扣进行治疗性穿透性角膜移植术。结论：虽然类风湿性关节炎可能是角膜溃疡形成的主要原因，但在诊断前局部使用糖皮质激素可加速胶孢炭疽菌的生长。
Background: Corneal infection of Colletotrichum gloeosporioides is uncommon and usually limited to the anterior stroma. However, we observed a case of corneal stromal perforation caused by this fungus under a compromised condition. Case: A 73-year-old woman consulted us with a severe corneal ulceration. She was a tangerine orange farmer who suffered from rheumatoid arthritis for more than ten years. Before consultation with us, she received pterygium excision in her right eye. She then developed a corneal ulceration and received topical glucocorticoid therapy upon diagnosis of rheumatoid arthritis-related stromal ulcer in the eye. At the first consultation with us, a corneal ulceration was observed in the inferotemporal area of her right cornea. Biological examination detected a filamentous fungus, Colletotrichum gloeosporioides. Topical and systemic antifungal treatments were not significantly effective. Fourteen days after consultation, the lesion grew worse, leading to stromal perforation, which was treated by therapeutic penetrating keratoplasty using a preserved corneal button. Conclusions: Topical glucocorticoid could accelerate the growth of Colletotrichum gloeosporioides before diagnosis, even though the primary cause of corneal ulceration development might be rheumatoid arthritis.
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影响因子：
3.6
作者：
Pote, S. T.;Chakraborty, A.;Shah, S. R.
通讯作者：
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影响因子：
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作者：
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影响因子：
13.8
作者：
O'Quinn, RP;Hoffmann, JL;Boyd, AS
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Boyd, AS
影响因子：
2.8
作者：
Yamamoto, N;Matsumoto, T;Ishibashi, Y
通讯作者：
Ishibashi, Y
DOI：
10.1016/j.oftal.2015.07.008
发表时间：
2016-02-01
影响因子：
--
作者：
Lamarca, J;Vilaplana, F;Barraquer, R I
通讯作者：
Barraquer, R I