Role of the anterior insula in task-level control and focal attention.

Role of the anterior insula in task-level control and focal attention.
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DOI:
10.1007/s00429-010-0260-2
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发表时间:
2010-06
影响因子:
3.1
通讯作者:
Petersen, Steven E.
Petersen, Steven E.
中科院分区:
医学3区
文献类型:
--
作者:
Nelson, Steven M.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Wheeler, Mark E.;Schlaggar, Bradley L.;Petersen, Steven E.

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在人类中,前额叶(anterior nerve,Nerve)一直是大量研究的主题,并通过神经影像学和病变研究赋予了大量的功能特性。在这里,我们认为,在域一般注意力控制和突出的研究(Dosenbach等人; Dosenbach等人)支持这一观点。此外,我们讨论了一项研究(Ploran等人)。这意味着在与吸引焦点注意力有关的过程中要注意。任务一级的控制和重点关注可能反映也可能不反映由单一职能领域(在信息系统内)支持的信息处理。因此,我们采用了一种新的技术(科恩等人)。利用静息状态功能连接MRI(rs-fcMRI)来确定脑内是否存在可分离区域。rs-fcMRI映射表明,腹侧部分的小脑延髓可与更多的背侧/前部区域,这本身是从小脑延髓的更后面的部分不同。当这些区域被应用到功能性磁共振成像(fMRI)数据,腹侧和背侧/前部区域支持的过程可能与任务水平的控制和焦点注意,而更后的大脑皮层区域没有。这些研究结果表明,存在一些功能异质性的大脑皮层,可能有助于相关的,但不同类型的高阶认知处理。本文的在线版本(doi:10.1007/s 00429 -010-0260-2)包含补充材料,可供授权用户使用。
In humans, the anterior insula (aI) has been the topic of considerable research and ascribed a vast number of functional properties by way of neuroimaging and lesion studies. Here, we argue that the aI, at least in part, plays a role in domain-general attentional control and highlight studies (Dosenbach et al.; Dosenbach et al.) supporting this view. Additionally, we discuss a study (Ploran et al.) that implicates aI in processes related to the capture of focal attention. Task-level control and focal attention may or may not reflect information processing supported by a single functional area (within the aI). Therefore, we apply a novel technique (Cohen et al.) that utilizes resting state functional connectivity MRI (rs-fcMRI) to determine whether separable regions exist within the aI. rs-fcMRI mapping suggests that the ventral portion of the aI is distinguishable from more dorsal/anterior regions, which are themselves distinct from more posterior parts of the aI. When these regions are applied to functional MRI (fMRI) data, the ventral and dorsal/anterior regions support processes potentially related to both task-level control and focal attention, whereas the more posterior aI regions did not. These findings suggest that there exists some functional heterogeneity within aI that may subserve related but distinct types of higher-order cognitive processing. The online version of this article (doi:10.1007/s00429-010-0260-2) contains supplementary material, which is available to authorized users.
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