The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.
The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.
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DOI：
10.1016/j.antiviral.2015.02.011
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发表时间：
2015-05
影响因子：
7.6
通讯作者：
Bray, Mike
中科院分区：
文献类型：
--
作者：
Davis, A. Sally;Taubenberger, Jeffery K.;Bray, Mike
在实验室动物身上复制人类流感特征的尝试可以追溯到19世纪90年代初，当时理查德·法伊弗用从流感患者那里恢复的细菌接种猿类，并产生了一种轻微的呼吸道疾病。在1918年大流行期间和随后的十年中，进行了大量使用非人类灵长类动物(NHP)的研究。大多数人使用细菌制剂感染动物，但也有一些人寻求一种可过滤的疾病制剂。自从流感的病毒病原学在20世纪30年代初确立以来，在小鼠、雪貂和人类志愿者身上进行的大量实验补充了对NHP的研究。然而，1976年出现了一种新的猪源H1N1流感病毒，1997年出现了高致病性H5N1禽流感病毒，这刺激了NHP研究的增加，因为这些药物很难在自然感染的患者身上研究，也不能在人类志愿者身上使用。在这篇文章中，我们回顾了从1893年到2014年底在流感研究中使用NHP的已发表文献。第一部分概述了对野生和圈养灵长类动物中自然发生的流感样综合征的观察研究，包括血清学调查。第二份报告按时间顺序介绍了NHP的实验性感染，从Pfeiffer的研究开始，涵盖了所有已发表的季节性和大流行性流感病毒研究，包括疫苗和抗病毒药物测试。第三部分回顾了自1997年以来引起人类疾病的禽流感病毒对NHP的实验性感染。文章最后提出了进一步研究的建议，以更清楚地定义和优化NHP作为流感研究实验动物的作用。
Attempts to reproduce the features of human influenza in laboratory animals date from the early 1890s, when Richard Pfeiffer inoculated apes with bacteria recovered from influenza patients and produced a mild respiratory illness. Numerous studies employing nonhuman primates (NHPs) were performed during the 1918 pandemic and the following decade. Most used bacterial preparations to infect animals, but some sought a filterable agent for the disease. Since the viral etiology of influenza was established in the early 1930s, studies in NHPs have been supplemented by a much larger number of experiments in mice, ferrets and human volunteers. However, the emergence of a novel swine-origin H1N1 influenza virus in 1976 and the highly pathogenic H5N1 avian influenza virus in 1997 stimulated an increase in NHP research, because these agents are difficult to study in naturally infected patients and cannot be administered to human volunteers. In this paper, we review the published literature on the use of NHPs in influenza research from 1893 through the end of 2014. The first section summarizes observational studies of naturally occurring influenza-like syndromes in wild and captive primates, including serologic investigations. The second provides a chronological account of experimental infections of NHPs, beginning with Pfeiffer’s study and covering all published research on seasonal and pandemic influenza viruses, including vaccine and antiviral drug testing. The third section reviews experimental infections of NHPs with avian influenza viruses that have caused disease in humans since 1997. The paper concludes with suggestions for further studies to more clearly define and optimize the role of NHPs as experimental animals for influenza research.
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DOI：
10.1038/icb.1941.43
发表时间：
1941-01-01
期刊：
AUSTRALIAN JOUR EXP BIOL AND MED SCI
影响因子：
--
作者：
BURNET, F. M.
通讯作者：
BURNET, F. M.
影响因子：
9.4
作者：
Butt, KM;Smith, GJD;Guan, Y
通讯作者：
Guan, Y
影响因子：
3.1
作者：
BERENDT, RF;HALL, WC
通讯作者：
HALL, WC
影响因子：
4.4
作者：
BERGMANN, KC;WALDMAN, RH;TISCHNER, H
通讯作者：
TISCHNER, H
影响因子：
5.4
作者：
Baas, T.;Baskin, C. R.;Katze, M. G.
通讯作者：
Katze, M. G.