Altered default mode network connectivity in Alzheimer's disease--a resting functional MRI and Bayesian network study.
Altered default mode network connectivity in Alzheimer's disease--a resting functional MRI and Bayesian network study.
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DOI：
10.1002/hbm.21153
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发表时间：
2011-11
影响因子：
4.8
通讯作者：
Yao, Li
中科院分区：
文献类型：
--
作者：
Wu, Xia;Li, Rui;Fleisher, Adam S.;Reiman, Eric M.;Guan, Xiaoting;Zhang, Yumei;Chen, Kewei;Yao, Li
许多功能磁共振成像(FMRI)研究报告了默认模式网络(DMN)的存在及其由于阿尔茨海默病(AD)等疾病的存在而中断。在本次研究中，我们首先使用独立成分分析(ICA)技术来证实先前报道的AD患者和正常对照组(NC)之间DMN的差异。与以往的研究结果一致，AD患者DMN的静息状态功能连接性降低存在于后扣带回(PCC)、内侧前额叶皮质(MPFC)、顶下皮质(IPC)、颞叶下皮质(ITC)和海马区(HC)。此外，我们还引入了贝叶斯网络(BN)来研究DMN的有效连通性以及AD和NC之间的区别。用非参数随机排列检验比较AD组和NC组的DMN有效连接性，发现左侧HC到左侧IPC、左侧ITC到右侧HC、右侧HC到左侧IPC、MPFC和PCC的连接均丢失。AD组右侧HC与左侧HC、左侧HC与左侧ITC、右侧IPC与右侧ITC的连接方向与NC组相反。除左侧HC外，右侧HC与BN内其他区域的联系均为0，提示AD患者右侧海马区的病理和功能负荷增加。AD患者的有效连接性改变可能揭示疾病的更多特征，并可能作为一个潜在的生物标志物。
A number of functional magnetic resonance imaging (fMRI) studies reported the existence of default mode network (DMN) and its disruption due to the presence of a disease such as Alzheimer’s disease (AD). In this current investigation, firstly, we used the independent component analysis (ICA) technique to confirm the DMN difference between patients with AD and normal control (NC) reported in previous studies. Consistent with previous studies, the decreased resting-state functional connectivity of DMN in AD was identified in posterior cingulated cortex (PCC), medial prefrontal cortex (MPFC), inferior parietal cortex (IPC), inferior temporal cortex (ITC) and hippocampus (HC). Moreover, we introduced Bayesian Network (BN) to study the effective connectivity of DMN and the difference between AD and NC. Compared the DMN effective connectivity in AD to the one in NC using a non-parametric random permutation test, we found that connections from left HC to left IPC, left ITC to right HC, right HC to left IPC, to MPFC and to PCC were all lost. In addition, in AD group, the connection directions between right HC and left HC, between left HC and left ITC, and between right IPC and right ITC were opposite to those in NC group. The connections of right HC to other regions, except left HC, within the BN were all statistically in-distinguishable from 0, suggesting an increased right hippocampal pathological and functional burden in AD. The altered effective connectivity in patients with AD may reveal more characteristics of the disease and may serve as a potential biomarker.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
5.7
作者：
Calhoun, VD;Adali, T;Pearlson, GD
通讯作者：
Pearlson, GD
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
5.7
作者：
Fripp, Jurgen;Bourgeat, Pierrick;Ourselin, Sebastien
通讯作者：
Ourselin, Sebastien