Histocompatibility leukocyte antigen and erythrocyte MNSs specificities in patients with meningitis or epiglottitis due to Haemophilus influenzae type b.

Histocompatibility leukocyte antigen and erythrocyte MNSs specificities in patients with meningitis or epiglottitis due to Haemophilus influenzae type b.
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b 型流感嗜血杆菌引起的脑膜炎或会厌炎患者的组织相容性白细胞抗原和红细胞 MNS 特异性。

DOI:
10.1093/infdis/149.3.373
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发表时间:
1984
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Rodey,GE
Rodey,GE
中科院分区:
--
文献类型:
--
作者:
Granoff,DM;Boies,EG;Squires,JE;Pandey,JP;Suarez,BK;Oldfather,JW;Rodey,GE

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本文对b型流感嗜血杆菌所致脑膜炎或会厌炎的白人患者和对照组的红细胞MNSS抗原和某些组织相容性白细胞抗原(HLA-A、HLA-B和HLA-DR)的频率进行了测定。脑膜炎患者的红细胞MNSs基因频率显著低于会厌患者(p=0.03);这一观察结果证实了以前观察到的趋势。然而,在被研究的三组中,人类白细胞抗原特异性的频率没有显著差异;这一结果未能证实先前关于疾病与几种人类白细胞抗原-A和人类白细胞抗原-B特异性相关的报道。尽管血友病对不同临床表现的易感性可能受到遗传因素的影响,但我们的研究表明,导致易感性的主要基因座与主要组织相容性复合体的特异性并不连锁不平衡。
The frequencies of erythrocyte MNSs antigens and certain histocompatibility leukocyte antigen (HLA) specificities (HLA-A, HLA-B, and HLA-DR) were determined in white patients with meningitis or epiglottitis due toHaemophilus influenzaetype b and in controls. The frequency of the erythrocyteMNSsgenotype was significantly lower among patients with meningitis than among those with epiglottitis (p= 0.03); this observation confirms a trend observed previously. However, the frequencies of the HLA specificities did not differ significantly in the three groups studied; this result fails to confirm previous reports of disease associations with several HLA-A and HLA-B specificities. Although susceptibility to different clinical manifestations of haemophilus disease may be influenced by genetic factors, our studies indicate that the major loci conferring susceptibility are not in linkage disequilibrium with specificities in the major histocompatibility complex.
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