Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans.
Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans.
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DOI：
10.1038/ejcn.2012.98
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发表时间：
2012-09
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
膳食纤维的结肠发酵可能通过短链脂肪酸（SCFA）减少游离脂肪酸（FFA）的代谢作用来改善胰岛素敏感性。本研究的主要目的是比较血浆胰岛素水平正常（<40 pmol/L，NI）和高（≥ 40 pmol/L，HI）的受试者外周醋酸盐（AC）摄取以及AC降低两组FFA的能力。整夜禁食的NI（n = 9）和HI（n = 9）参与者在90分钟内以3种不同速率静脉（IV）输注140 mmol/L醋酸钠。AC输注总量为51.85 mmol。NI受试者的醋酸盐清除率与HI受试者无显著差异（2.11 ± 0.23 vs 2.09 ± 0.24 ml/min）。FFA在两组中均下降，但NI组的反弹程度大于HI组（时间×组间相互作用，P = 0.001）。还观察到IV AC输注期间胰岛素抵抗（IR）指数（HOMA-IR、Matsuda和胰岛素原指数）与FFA反弹之间存在显著相关性。这些结果表明，AC摄取在两组中是相似的。低血浆胰岛素和低IR指数的参与者FFA反弹更大。这些结果支持了这样的假设，即增加体循环中AC浓度可减少脂解和血浆FFA浓度，从而改善胰岛素敏感性。需要进行更深入的研究来观察SCFA对胰岛素抵抗参与者FFA代谢的影响。
Colonic fermentation of dietary fiber may improve insulin sensitivity via the metabolic effects of short chain fatty acids (SCFA) in reducing free fatty acids (FFA). The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (< 40pmol/L, NI) and high (≥ 40pmol/L, HI) plasma-insulin and the ability of AC to reduce FFA in both groups. Overnight fasted NI (n = 9) and HI (n = 9) participants were given an intravenous (IV) infusion of 140 mmol/L sodium acetate at 3 different rates over 90 minutes. The total amount of AC infused was 51.85 mmols. Acetate clearance in NI participants was not significantly different than that in HI participants (2.11 ± 0.23 vs 2.09 ± 0.24 ml/min). FFA fell in both groups, but rebounded to a greater extent in NI than HI participants (time × group interaction, P = 0.001). Significant correlations between insulin resistance (IR) indices (HOMA-IR, Matsuda and Insulinogenic Index) vs FFA rebound during IV AC infusion were also observed. These findings suggest that AC uptake is similar in both groups. Participants with lower plasma insulin and lower IR indices had a greater FFA rebound. These results support the hypothesis that increasing AC concentrations in the systemic circulation may reduce lipolysis and plasma FFA concentrations and thus improve insulin sensitivity. More in-depth studies are needed to look at the effects of SCFA on FFA metabolism in insulin resistant participants.
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影响因子：
4.1
作者：
BUCKLEY, BM;WILLIAMSON, DH
通讯作者：
WILLIAMSON, DH
DOI：
10.1152/ajpendo.00430.2004
发表时间：
2005-10-01
影响因子：
5.1
作者：
Ferchaud-Roucher, V;Pouteau, E;Krempf, M
通讯作者：
Krempf, M
影响因子：
7.7
作者：
Kelley, DE;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
7.1
作者：
McKeown, NM;Meigs, JB;Jacques, PF
通讯作者：
Jacques, PF
影响因子：
7.1
作者：
JENKINS, DJA;WOLEVER, TMS;PATTEN, R
通讯作者：
PATTEN, R