Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding.
Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding.
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DOI：
10.1111/irv.12563
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发表时间：
2018-09
影响因子：
4.4
通讯作者：
Aiello AE
中科院分区：
文献类型：
--
作者：
Davis BM;Foxman B;Monto AS;Baric RS;Martin ET;Uzicanin A;Rainey JJ;Aiello AE
4种最常见的人类冠状病毒（HCoV）-229 E、HKU 1、NL 63和OC 43感染者的患病率、症状病程和脱落情况描述不足。我们估计他们的患病率和相关的症状，通过社会网络研究设计确定的大学生。我们在2012年10月至2013年1月17日期间从176名受试者中采集了1 - 3份样本（n = 250份标本）：患有急性呼吸道感染（ARI;咳嗽和身体疼痛或寒战或发热/发烧）的受试者及其社会接触者。使用RT-PCR检测病毒。30.4%（76/250）的标本对任何检测的病毒检测呈阳性，4.8%（12/250）的标本对2种或2种以上病毒检测呈阳性。人冠状病毒（HCoV [22.0%; 55/250]）、鼻病毒（7.6%; 19/250）和甲型流感（6.4%; 16/250）最常见。在患有HCoV的ARI参与者中，症状随着时间的推移发生了显著变化：咳嗽和寒战的患病率在6天内下降（分别为P =.04和P =.01），而同期流鼻涕的患病率增加（P =.02）。HCoV-NL 63是症状发作后6天检测到的最常见病毒（8.9%），其次是鼻病毒（6.7%）。在涵盖单一季节的3个月期间，HCoV很常见，即使在没有呼吸道症状的社会接触中也是如此;特定症状可能会在HCoV相关疾病的过程中发生变化，并且与流感和鼻病毒的症状相似。
The prevalence, symptom course, and shedding in persons infected with the 4 most common human coronaviruses (HCoV)‐229E, HKU1, NL63, and OC43 are poorly described. We estimate their prevalence and associated symptoms among college students identified via a social network study design. We collected 1‐3 samples (n = 250 specimens) from 176 participants between October 2012 and January 17, 2013: participants with acute respiratory infection (ARI; cough and body aches or chills or fever/feverishness) and their social contacts. Virus was detected using RT‐PCR. 30.4% (76/250) of specimens tested positive for any virus tested, and 4.8% (12/250) were positive for 2 or more viruses. Human coronaviruses (HCoVs [22.0%; 55/250]), rhinovirus (7.6%; 19/250), and influenza A (6.4%; 16/250) were most prevalent. Symptoms changed significantly over time among ARI participants with HCoV: the prevalence of cough and chills decreased over 6 days (P = .04, and P = .01, respectively), while runny nose increased over the same period (P = .02). HCoV‐NL63 was the most frequent virus detected 6 days following symptom onset (8.9%), followed by rhinovirus (6.7%). During a 3‐month period covering a single season, HCoVs were common, even among social contacts without respiratory symptoms; specific symptoms may change over the course of HCoV‐associated illness and were similar to symptoms from influenza and rhinovirus.
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影响因子：
11.8
作者：
Chiu, SS;Chan, KH;Peiris, JSM
通讯作者：
Peiris, JSM
影响因子：
8.8
作者：
Esper, Frank;Ou, Zhen;Huang, Yung T.
通讯作者：
Huang, Yung T.
影响因子：
11.8
作者：
Pfefferle S;Oppong S;Drexler JF;Gloza-Rausch F;Ipsen A;Seebens A;Müller MA;Annan A;Vallo P;Adu-Sarkodie Y;Kruppa TF;Drosten C
通讯作者：
Drosten C
影响因子：
11.8
作者：
Vabret, A;Mourez, T;Freymuth, F
通讯作者：
Freymuth, F
DOI：
10.3181/00379727-121-30734
发表时间：
1966-01-01
影响因子：
--
作者：
HAMRE, D;PROCKNOW, JJ
通讯作者：
PROCKNOW, JJ