Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura.
Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura.
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减少胼胝体分数各向异性调节无先兆偏头痛患者的半球间静息状态功能连接
DOI：
10.1371/journal.pone.0045476
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Yuan K;Qin W;Liu P;Zhao L;Yu D;Zhao L;Dong M;Liu J;Yang X;von Deneen KM;Liang F;Tian J
背景扩散张量成像（DTI）研究显示，无先兆偏头痛患者胼胝体（CC）的各向异性分数（FA）值降低。白色物质完整性的缺失，特别是CC，可能会影响半球间静息态功能连接（RSFC）。不幸的是，相对知之甚少的改变，在休息状态下，在偏头痛患者的大脑半球之间的功能相互作用没有先兆，甚至更少关于如何间半球RSFC的影响，由CC的异常。方法和结果21名无先兆偏头痛患者和21名健康对照者参加了这项研究，年龄，性别和教育相匹配。基于道的空间统计（TBSS）调查的白色物质的变化的CC。同时，采用体素镜像同伦连接（VMHC）技术比较患者和对照组间半球间RSFC的差异。TBSS分析显示，患者组CC的前襟和压部FA值降低。VMHC分析显示，相对于对照组，无先兆偏头痛患者的前扣带皮层（ACC）的半球间RSFC减少。此外，在没有先兆的偏头痛患者中，结论无先兆偏头痛患者CC的FA值降低，ACC的半球间RSFC降低，上述结构和功能改变之间的相关性提示，CC的FA值降低，ACC的半球间RSFC降低，可能与CC的FA值降低有关。CC调节无先兆偏头痛患者的半球间VMHC。结果表明，无先兆偏头痛患者ACC VMHC改变可反映CC区FA改变。
Background Diffusion tensor imaging (DTI) study revealed reduced fractional anisotropy (FA) values in the corpus callosum (CC) in migraine patients without aura. Abnormalities in white matter integrity, particularly in the CC, may affect inter-hemispheric resting state functional connectivity (RSFC). Unfortunately, relatively little is known about the alterations in functional interactions between the cerebral hemispheres during resting state in migraine patients without aura, and even less about how the inter-hemispheric RSFC are affected by the abnormalities of the CC. Methods and findings Twenty-one migraine patients without aura and 21 healthy controls participated in this study, age-, sex-, and education-matched. Tract-based spatial statistics (TBSS) was employed to investigate the white matter alterations of the CC. Meanwhile, voxel-mirrored homotopic connectivity (VMHC) was used to compare the inter-hemispheric RSFC differences between the patients and controls. TBSS analysis revealed reduced FA values in the genu and the splenium of CC in patient group. VMHC analysis showed decreased inter-hemispheric RSFC of anterior cingulate cortex (ACC) in migraine patients without aura relative to that of the controls. Furthermore, in migraine patients without aura, the reduced FA values of the genu of CC correlated with the decreased inter-hemispheric RSFC of the ACC. Conclusions Our findings demonstrated that the migraine patients without aura showed reduced FA values of the genu of CC and decreased inter-hemispheric RSFC of the ACC. The correlation between the above structural and functional changes suggested that the reduced fractional anisotropy (FA) of CC modulates inter-hemispheric VMHC in migraine patients without aura. Our results demonstrated that the VMHC alterations of ACC can reflect the FA changes of the genu of CC in migraine patients without aura.
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影响因子：
14.5
作者：
Afridi, SK;Matharu, MS;Goadsby, PJ
通讯作者：
Goadsby, PJ
不对称的连通性降低及其与大脑衰老的“哈罗德”的关系。
影响因子：
2.9
作者：
Li, Zhihao;Moore, Anna Bacon;Tyner, Callie;Hu, Xiaoping
通讯作者：
Hu, Xiaoping
DOI：
10.1073/pnas.0907655106
发表时间：
2009-11-17
影响因子：
11.1
作者：
Caminiti, Roberto;Ghaziri, Hassan;Innocenti, Giorgio M.
通讯作者：
Innocenti, Giorgio M.
影响因子：
4.9
作者：
Kim, J. H.;Suh, S. -I;Koh, S-B
通讯作者：
Koh, S-B
影响因子：
10.6
作者：
Kelly, Clare;Zuo, Xi-Nian;Gotimer, Kristin;Cox, Christine L.;Lynch, Lauren;Brock, Dylan;Imperati, Davide;Garavan, Hugh;Rotrosen, John;Castellanos, F. Xavier;Milham, Michael P.
通讯作者：
Milham, Michael P.