In-Depth Analyses of the Effects of a Diet and Resistance Exercise Intervention in Older Adults: Who Benefits Most From ProMuscle in Practice?
In-Depth Analyses of the Effects of a Diet and Resistance Exercise Intervention in Older Adults: Who Benefits Most From ProMuscle in Practice?
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DOI：
10.1093/gerona/glab104
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发表时间：
2021-11-15
期刊：
影响因子：
--
通讯作者：
Haveman-Nies A
中科院分区：
文献类型：
--
作者：
Dorhout BG;Doets EL;van Dongen EJI;de Groot LCPGM;Haveman-Nies A
ProMuscle在实践中的干预，包括阻力运动和增加蛋白质摄入量，是有效的改善肌肉力量，瘦体重，和身体功能的老年人年龄在65岁及以上（N = 168）。 然而，对这些干预措施的反应往往不一。因此，我们探讨了基于人口统计学特征和活动障碍的亚组对干预的反应性差异。进行多元回归分析，以研究基线和12周之间的短体力活动成套测验、椅子起身试验、瘦体重、膝关节伸展力量、腿部按压力量和腿部伸展力量的平均变化。纳入了相互作用项治疗×亚组，以研究亚组之间的效应差异。 亚组包括年龄（≤75岁vs >75岁）、性别（男性vs女性）、存在虚弱、存在肌肉减少症和存在骨关节炎。包括年龄在内的显著交互作用对瘦体重有影响（β = −0.8; 95%CI：−1.5，−0.2），有利于年龄在75岁及以下的参与者。 发现包括性别在内的显著交互作用对腿部按压力量有影响（β = 15.5; 95% CI：0.6，30.3），女性更受青睐。 参与者有或没有虚弱，肌肉减少症，或骨关节炎的干预措施的绝对效果相同。 75岁及以下的参与者和女性在很大程度上受益于干预，因为他们几乎在每一个结果上都有显着改善。有和没有行动障碍的参与者的效果是相当的，这表明干预适合两组。
The ProMuscle in Practice intervention, comprising resistance exercise and an increased protein intake, was effective in improving muscle strength, lean body mass, and physical functioning in older adults aged 65 years and older (N = 168). However, a heterogeneous response to such interventions is common. Therefore, we explored the differences in responsiveness to the intervention in subgroups based on demographic characteristics and mobility-impairing disorders. Multiple regression analyses were performed to study mean changes between baseline and 12 weeks on the Short Physical Performance Battery, chair rise test, lean body mass, knee extension strength, leg press strength, and leg extension strength. The interaction term Treatment × Subgroup was included to study differences in effects between subgroups. Subgroups comprised age (≤75 vs >75 years), sex (men vs women), presence of frailty, presence of sarcopenia, and presence of osteoarthritis. A significant interaction effect including age was found on lean body mass (β = −0.8; 95% CI: −1.5, −0.2), favoring participants aged 75 years and younger. A significant interaction effect including sex was found on leg press strength (β = 15.5; 95% CI: 0.6, 30.3), favoring women. Participants with or without frailty, sarcopenia, or osteoarthritis responded equally to the intervention in terms of absolute effects. Participants aged 75 years and younger and women benefited to a great extent from the intervention, as they improved significantly on nearly every outcome. Effects in participants with and without a mobility-impairing disorder were comparable, indicating that the intervention is suitable for both groups.
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影响因子：
4
作者：
de Zwart, A. H.;van der Leeden, M.;Dekker, J.
通讯作者：
Dekker, J.
影响因子：
7.1
作者：
Cermak, Naomi M.;Res, Peter T.;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.
影响因子：
2.5
作者：
Da Boit M;Sibson R;Meakin JR;Aspden RM;Thies F;Mangoni AA;Gray SR
通讯作者：
Gray SR
影响因子：
2.2
作者：
Jones, CJ;Rikli, RE;Beam, WC
通讯作者：
Beam, WC
影响因子：
5.8
作者：
Hidayat, K.;Chen, G. -C.;Qin, L. -Q.
通讯作者：
Qin, L. -Q.