Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions.
Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions.
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DOI：
10.3389/fpsyt.2023.1196235
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发表时间：
2023
影响因子：
4.7
通讯作者：
Tagaya, Hirokuni
中科院分区：
文献类型：
--
作者：
Hakamata, Yuko;Hori, Hiroaki;Mizukami, Shinya;Izawa, Shuhei;Yoshida, Fuyuko;Moriguchi, Yoshiya;Hanakawa, Takashi;Inoue, Yusuke;Tagaya, Hirokuni
关键词：
免疫系统在大脑和相关的精神病理学中起着重要作用。干扰白细胞介素-6分泌和异常杏仁核情绪反应在压力相关的精神障碍中有很好的记录。杏仁核调节受相关基因影响的心理社会压力相关白细胞介素-6。这些使我们全面研究基因-应激相互作用下白细胞介素-6、杏仁核活性和应激相关精神症状之间的关系。108名患有不同程度焦虑/抑郁的非临床参与者在情绪面部任务期间接受了杏仁核活动和唾液收集（在2天内的10个时间点）的总输出和白细胞介素-6的昼夜模式的磁共振成像扫描。探讨了rs 1800796（C/G）和rs 2228145（C/A）之间的基因-应激源相互作用以及用于生物行为测量的应激生活事件。白细胞介素-6昼夜模式的钝化与基底外侧杏仁核对恐惧面孔（与中性面孔）的低激活有关（t = 3.67，FWE校正的p = 0.003），并且主要在具有rs 1800796 C等位基因纯合子和过去一年生活发生负面变化的个体中观察到（F = 19.71，p < 0.001）。当在综合模型中考虑时，减少的昼夜模式预测了更大的抑郁症状（β =-0.40），受到杏仁核活动减退（β = 0.36）和rs 1800796-压力源相互作用（β =-0.41;所有p < 0.001）的调节。在这里，我们表明，钝白细胞介素-6昼夜节律预测抑郁症状，杏仁核情绪低反应性和基因应激相互作用调制。这些发现表明了抑郁症易感性的潜在机制，表明通过了解免疫系统失调可以早期发现，预防和治疗抑郁症。
The immune system has major roles in the brain and related psychopathology. Disrupted interleukin-6 secretion and aberrant amygdala emotional reactivity are well-documented in stress-related mental disorders. The amygdala regulates psychosocial stress-related interleukin-6 affected by related genes. These led us to comprehensively examine the relationship between interleukin-6, amygdala activity, and stress-related mental symptoms under gene-stressor interactions. One hundred eight nonclinical participants with various levels of anxiety/depression underwent magnetic resonance imaging scans during an emotional face task for amygdala activity and saliva collection (at 10-time points across 2 days) for the total output and diurnal patterns of interleukin-6. Gene-stressor interactions between rs1800796 (C/G) and rs2228145 (C/A) and stressful life events for the biobehavioral measures were explored. The blunting of interleukin-6 diurnal pattern was associated with hypoactivation of the basolateral amygdala in response to fearful (vs. neutral) faces (t = 3.67, FWE-corrected p = 0.003), and was predominantly observed in individuals with rs1800796 C-allele homozygotes and negative life changes in the past year (F = 19.71, p < 0.001). When considered in a comprehensive model, the diminished diurnal pattern predicted greater depressive symptoms (β = −0.40), modulated by the amygdala hypoactivity (β = 0.36) and rs1800796-stressor interactions (β = −0.41; all p < 0.001). Here we show that the blunted interleukin-6 diurnal rhythm predicts depressive symptoms, modulated by amygdala emotional hyporeactivity and gene-stressor interactions. These findings indicate a potential mechanism underlying vulnerability to depressive disorders, suggesting their early detection, prevention, and treatment through the understanding of immune system dysregulation.
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影响因子：
4.2
作者：
Alvarez GM;Hackman DA;Miller AB;Muscatell KA
通讯作者：
Muscatell KA
影响因子：
11
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
通讯作者：
Martin NG
影响因子：
14.9
作者：
Cariaso M;Lennon G
通讯作者：
Lennon G
DOI：
10.1002/bs.3830190102
发表时间：
1974-01-01
期刊：
BEHAVIORAL SCIENCE
影响因子：
--
作者：
DEROGATIS, LR;LIPMAN, RS;COVI, L
通讯作者：
COVI, L
影响因子：
5.6
作者：
Battaglia, Simone;Di Fazio, Chiara;Vicario, Carmelo M.;Avenanti, Alessio
通讯作者：
Avenanti, Alessio