Dentin biomodification: strategies, renewable resources and clinical applications.
Dentin biomodification: strategies, renewable resources and clinical applications.
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DOI：
10.1016/j.dental.2013.10.012
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发表时间：
2014-01
期刊：
影响因子：
5
通讯作者：
Leme, Ariene A.
中科院分区：
文献类型：
--
作者：
Bedran-Russo, Ana K.;Pauli, Guido F.;Chen, Shao-Nong;McAlpine, James;Castellan, Carina S.;Phansalkar, Rasika S.;Aguiar, Thaiane R.;Vidal, Cristina M. P.;Napotilano, Jose G.;Nam, Joo-Won;Leme, Ariene A.
关键词：
牙本质的生物改性是通过生物活性物质的作用，局部改变牙本质的生物化学和生物力学性质，从而达到增强和强化牙本质的目的。本文综述了牙本质基质的主要成分、生物修饰策略的靶向作用、可再生天然资源的化学性质及其潜在临床应用的研究现状。PubMed数据库和收集的文献被用作同行评审文章的资源，以突出牙本质层次结构，生物修饰剂及其临床应用的实验室研究的主题。此外，新的数据提出了实验室方法的标准化的原花青素丰富的制剂作为一种可再生来源的植物衍生的生物改性剂。生物改性剂可分为物理方法和化学方法。合成和天然存在的化学策略呈现与组织相互作用的独特机制。最初认为仅由分子间或分子内胶原诱导的非酶胶原交联驱动，与其他牙本质组分的多种相互作用是组织长期生物力学和生物稳定性的基础。低聚原花青素显示出有前途的生物活性，其化学复杂性需要系统评价的活性化合物，以产生一个完全标准化的干预材料，从可再生资源，在其详细的临床评价。了解牙本质的层次结构和生物活性化合物的靶向作用将建立它们在牙本质-生物材料界面和龋管理中的应用。
The biomodification of dentin is a biomimetic approach, mediated by bioactive agents, to enhance and reinforce the dentin by locally altering the biochemistry and biomechanical properties. This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications. The PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and laboratorial investigations of their clinical applications. In addition, new data is presented on laboratorial methods for the standardization of proanthocyanidin-rich preparations as a renewable source of plant-derived biomodification agents. Biomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter- or intra-molecular collagen induced non-enzymatic collagen cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics and biostability of the tissue. Oligomeric proanthocyanidins show promising bioactivity, and their chemical complexity requires systematic evaluation of the active compounds to produce a fully standardized intervention material from renewable resource, prior to their detailed clinical evaluation. Understanding the hierarchical structure of dentin and the targeting effect of the bioactive compounds will establish their use in both dentin-biomaterials interface and caries management.
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影响因子：
4.4
作者：
Castellan, Carina Strano;Pereira, Patricia N. R.;Viana, Grace;Chen, Shao-Nong;Pauli, Guido F.;Bedran-Russo, Ana Karina
通讯作者：
Bedran-Russo, Ana Karina
DOI：
10.1016/j.jmbbm.2011.05.003
发表时间：
2011-10
影响因子：
3.9
作者：
Castellan, Carina Strano;Bedran-Russo, Ana Karina;Karol, Sachin;Rodrigues Pereira, Patricia Nobrega
通讯作者：
Rodrigues Pereira, Patricia Nobrega
影响因子：
2.9
作者：
CHEUNG, DT;PERELMAN, N;NIMNI, ME
通讯作者：
NIMNI, ME
影响因子：
14
作者：
Damink, LHHO;Dijkstra, PJ;Feijen, J
通讯作者：
Feijen, J
影响因子：
7.6
作者：
Cova, A.;Breschi, L.;Mazzoni, A.
通讯作者：
Mazzoni, A.