White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits.
White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits.
复制标题
诵读困难和孤立的拼写缺陷的儿童的白质改变和区域横向化。
DOI：
10.1002/hbm.24410
复制
发表时间：
2019-02-15
影响因子：
4.8
通讯作者：
Landerl K
中科院分区：
文献类型：
--
作者：
Banfi C;Koschutnig K;Moll K;Schulte-Körne G;Fink A;Landerl K
本研究调查是否有一个典型的阅读障碍的儿童和儿童孤立的拼写缺陷显示出一个独特的模式相比，典型的发展同龄人的白色物质的改变。关于这个主题的相关研究很少，依赖于小样本，并且经常受到传统张量方法的限制。目前的约束球面去卷积研究包括27名儿童与典型的阅读和拼写技能，21名儿童与诵读困难和21名儿童孤立的拼写缺陷。沿白色主要白质束的沿着组差异利用自动纤维定量软件进行定量，并计算偏侧化指数，以调查束的结构不对称性。两个缺陷组的白色物质改变主要表现为不同的模式，在阅读障碍组中位于双侧下纵束、右侧上级纵束和扣带，在孤立性拼写缺陷组中位于左侧弓状束。这两个赤字群体在结构不对称方面也有所不同。有阅读障碍的儿童没有表现出典型的弓状神经束的不对称性，而孤立的拼写缺陷组没有表现出下额枕神经束的不对称性。这项研究增加了证据的概念，不同的组合或单独的阅读和拼写缺陷的轮廓与不同的神经签名。
The present study investigated whether children with a typical dyslexia profile and children with isolated spelling deficits show a distinct pattern of white matter alteration compared with typically developing peers. Relevant studies on the topic are scarce, rely on small samples, and often suffer from the limitations of conventional tensor‐based methods. The present Constrained Spherical Deconvolution study includes 27 children with typical reading and spelling skills, 21 children with dyslexia and 21 children with isolated spelling deficits. Group differences along major white matter tracts were quantified utilizing the Automated Fiber Quantification software and a lateralization index was calculated in order to investigate the structural asymmetry of the tracts. The two deficit groups mostly displayed different patterns of white matter alterations, located in the bilateral inferior longitudinal fasciculi, right superior longitudinal fasciculus, and cingulum for the group with dyslexia and in the left arcuate fasciculus for the group with isolated spelling deficits. The two deficit groups differed also with respect to structural asymmetry. Children with dyslexia did not show the typical leftward asymmetry of the arcuate fasciculus, whereas the group with isolated spelling deficits showed absent rightward asymmetry of the inferior fronto‐occipital fasciculus. This study adds evidence to the notion that different profiles of combined or isolated reading and spelling deficits are associated with different neural signatures.
登录
查看更多内容
影响因子：
4.8
作者：
Lebel, Catherine;Beaulieu, Christian
通讯作者：
Beaulieu, Christian
影响因子：
5.7
作者：
Beaulieu, C;Plewes, C;Phillips, L
通讯作者：
Phillips, L
影响因子：
3.6
作者：
Deutsch, GK;Dougherty, RF;Wandell, B
通讯作者：
Wandell, B
影响因子：
11.2
作者：
Catani, M;Jones, DK;Ffytche, DH
通讯作者：
Ffytche, DH
影响因子：
16.6
作者：
Huber E;Donnelly PM;Rokem A;Yeatman JD
通讯作者：
Yeatman JD