Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges.
Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges.
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DOI：
10.3390/pharmaceutics15010194
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发表时间：
2023-01-05
期刊：
影响因子：
5.4
通讯作者：
Minko T
中科院分区：
文献类型：
--
作者：
Pozharov VP;Minko T
在过去的几十年里，已经开发出许多基于纳米技术和核酸的药物。然而，直到最近，它们中的大多数仍然处于临床前开发和测试阶段，没有进入临床。我们认为，这种情况的主要原因在于这种制剂的开发和工业生产的巨大复杂性，导致其成本高。纳米药物的研发需要来自不同专业的科学家参与，包括药剂学、医学、工程学、药物输送、化学、分子生物学、生理学等。然而，冠状病毒和基于纳米技术的新型疫苗的出现显示了这种方法的高效率。基于核酸和纳米医学的疫苗的有效开发需要理解广泛的原理，包括免疫应答机制，核酸功能，纳米技术和疫苗接种。在这方面，目前审查的目的是回顾免疫系统、疫苗接种、纳米技术和药物输送在基于纳米技术和使用核酸的疫苗的开发和生产方面的工作的基本原则。
Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids.
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影响因子：
13.3
作者：
Chen, Alex M.;Zhang, Min;Wei, Dongguang;Stueber, Dirk;Taratula, Oleh;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
影响因子：
17.1
作者：
Chen, Alex M.;Taratula, Oleh;Wei, Dongguang;Yen, Hsin-I;Thomas, Thresia;Thomas, T. J.;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
影响因子：
11.1
作者：
Dockrell, Hazel M.;McShane, Helen
通讯作者：
McShane, Helen
影响因子：
5.6
作者：
通讯作者：
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DOI：
10.1084/jem.20180314
发表时间：
2018-11-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Buxadé M;Huerga Encabo H;Riera-Borrull M;Quintana-Gallardo L;López-Cotarelo P;Tellechea M;Martínez-Martínez S;Redondo JM;Martín-Caballero J;Flores JM;Bosch E;Rodríguez-Fernández JL;Aramburu J;López-Rodríguez C
通讯作者：
López-Rodríguez C