Speech discrimination after early exposure to pulsed-noise or speech.
Speech discrimination after early exposure to pulsed-noise or speech.
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DOI：
10.1016/j.heares.2012.04.020
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发表时间：
2012-07
期刊：
影响因子：
2.8
通讯作者：
Kilgard, Michael P.
中科院分区：
文献类型：
--
作者：
Ranasinghe, Kamalini G.;Carraway, Ryan S.;Borland, Michael S.;Moreno, Nicole A.;Hanacik, Elizabeth A.;Miller, Robert S.;Kilgard, Michael P.
结构化输入和复杂声音特征的早期经验产生初级听觉皮层（A1）的音调和感受野特性的持久变化。在这项研究中，我们测试了这些变化是否严重到足以改变神经表征和言语行为辨别。我们将两组处于听觉发育关键期的幼鼠暴露于脉冲噪声或语音中。两组大鼠在成年后都接受了辨别语音的训练，并从A1记录了麻醉的神经反应。在A1和语音的行为歧视的语音的代表性仍然强大的A1神经元的频谱和时间特性改变脉冲噪声暴露后。在早期发育过程中暴露于被动言语并没有在言语声音处理方面提供额外的优势。言语训练增加了幼稚大鼠对言语刺激的A1神经元放电率，但没有增加早期暴露于脉冲噪声或言语的大鼠的反应。我们的研究结果表明，语音处理是抵抗简单的神经反应特性的变化所造成的操纵早期的声学环境。
Early experience of structured inputs and complex sound features generate lasting changes in tonotopy and receptive field properties of primary auditory cortex (A1). In this study we tested whether these changes are severe enough to alter neural representations and behavioral discrimination of speech. We exposed two groups of rat pups during the critical period of auditory development to pulsed noise or speech. Both groups of rats were trained to discriminate speech sounds when they were young adults, and anesthetized neural responses were recorded from A1. The representation of speech in A1 and behavioral discrimination of speech remained robust to altered spectral and temporal characteristics of A1 neurons after pulsed-noise exposure. Exposure to passive speech during early development provided no added advantage in speech sound processing. Speech training increased A1 neuronal firing rate for speech stimuli in naïve rats, but did not increase responses in rats that experienced early exposure to pulsed noise or speech. Our results suggest that speech sound processing is resistant to changes in simple neural response properties caused by manipulating early acoustic environment.
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