A H(2)O(2) self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy.
A H(2)O(2) self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy.
复制标题
用于热响应增强化学动力学治疗的具有多米诺效应的 H2O2 自给自足纳米平台
DOI：
10.1039/c9sc05506a
复制
发表时间：
2020-01-08
期刊：
影响因子：
8.4
通讯作者：
Dong X
中科院分区：
文献类型：
--
作者：
Zhang S;Cao C;Lv X;Dai H;Zhong Z;Liang C;Wang W;Huang W;Song X;Dong X
化学动力学疗法（CDT）利用芬顿或类芬顿催化剂将过氧化氢（H2O2）转化为有毒的羟基自由基（˙OH）来杀死癌细胞，由于其高选择性，在肿瘤治疗中具有很高的前景。然而，由于内源性H2O2浓度有限，其抗癌效果并不理想。在此，利用有机相变材料（PCM）封装铁-没食子酸纳米粒子（Fe-GA）和超小CaO2，制备了具有H2O2自给自足的热响应纳米粒子。 PCM 作为看门人，在激光照射下可以通过 Fe-GA 的热效应熔化，并突然释放出 Fe-GA 和 CaO2。酸性肿瘤微环境会进一步触发CaO2产生大量的H2O2和Ca2+。自提供的H2O2通过与Fe-GA参与芬顿反应而转化为˙OH。同时，原位产生的Ca2+可引起线粒体损伤并导致肿瘤细胞凋亡。体内光声成像显示了有效的肿瘤积累，Fe-GA/CaO2@PCM 表现出优异的体内肿瘤抑制作用，且不会引起全身毒性。该研究提出了一种独特的基于PCM的纳米粒子的多米诺效应方法，具有热响应性、H2O2自供给性和大大增强的CDT效应，为高效肿瘤治疗展现了光明的前景。基于相变材料的 H2O2 自供给纳米粒子，用于增强热响应化学动力学肿瘤治疗。
Chemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H2O2) into toxic hydroxyl radicals (˙OH) to kill cancer cells, holds high promise in tumor therapy due to its high selectivity. However, the anticancer efficacy is unsatisfactory owing to the limited concentration of endogenous H2O2. Herein, thermal responsive nanoparticles with H2O2 self-sufficiency are fabricated by utilizing organic phase change materials (PCMs) to encapsulate iron–gallic acid nanoparticles (Fe–GA) and ultra-small CaO2. PCMs, acting as the gatekeeper, could be melted down by the hyperthermia effect of Fe–GA under laser irradiation with a burst release of Fe–GA and CaO2. The acidic tumor microenvironment would further trigger CaO2 to generate a large amount of H2O2 and Ca2+. The self-supplied H2O2 would be converted into ˙OH by participating in the Fenton reaction with Fe–GA. Meanwhile, in situ generation of Ca2+ could cause mitochondrial damage and lead to apoptosis of tumor cells. With efficient tumor accumulation illustrated in in vivo photoacoustic imaging, Fe–GA/CaO2@PCM demonstrated a superior in vivo tumor-suppressive effect without inducing systemic toxicity. The study presents a unique domino effect approach of PCM based nanoparticles with thermal responsiveness, H2O2 self-supply, and greatly enhanced CDT effects, showing bright prospects for highly efficient tumor treatment. Phase change material based H2O2 self-supply nanoparticles for enhanced thermal responsive chemodynamic tumor therapy.
登录
查看更多内容
自组装金属-酚醛网络纳米颗粒的有毒活性氧增强协同组合疗法
影响因子：
29.4
作者：
Dai, Yunlu;Yang, Zhen;Chen, Xiaoyuan
通讯作者：
Chen, Xiaoyuan
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
29.4
作者：
Chen, Qian;Feng, Liangzhu;Liu, Zhuang
通讯作者：
Liu, Zhuang
用于增强余辉成像引导光热触发光动力治疗的“蜡封”治疗诊断纳米平台
影响因子：
19
作者：
Liu, Gongyuan;Zhang, Shichao;Dong, Xiaochen
通讯作者：
Dong, Xiaochen
通过纳米催化剂递送，肿瘤选择性催化纳米医学。
影响因子：
16.6
作者：
Huo M;Wang L;Chen Y;Shi J
通讯作者：
Shi J