Plasma and cerebrospinal fluid amyloid-β levels in late-life depression: A systematic review and meta-analysis.
Plasma and cerebrospinal fluid amyloid-β levels in late-life depression: A systematic review and meta-analysis.
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DOI：
10.1016/j.jpsychires.2015.07.024
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发表时间：
2015-10
影响因子：
4.8
通讯作者：
Diniz, Breno S.
中科院分区：
文献类型：
--
作者：
Fiaux do Nascimento, Kenia Kelly;Silva, Kelly P.;Malloy-Diniz, Leandro F.;Butters, Meryl A.;Diniz, Breno S.
本研究旨在评价老年抑郁症患者与非抑郁老年对照组相比血浆和脑脊液（CSF）中Aβ肽水平的差异。我们使用PubMed、Web of science和Scopus数据库对文献进行了系统回顾和荟萃分析，对出版日期或语言没有检索限制。两名独立的审查员提取数据并评估质量。共检索到600篇参考文献，我们在资格筛选后纳入了12项研究。与非抑郁受试者相比，老年抑郁症（LLD）患者的血浆Aβ40：Aβ42比值较高（SMD= 1.10，CI 95%[0.28; 1.96]，p=0.01），CSF Aβ42水平略微显著降低（SMD= −1.12，CI 95%[−2.47; 0.22]，p=0.1）。目前的结果表明，老年抑郁症患者的Aβ代谢存在显著差异，与AD患者的方向相同。Aβ代谢的这些差异可能有助于识别AD发生风险较高的LLD受试者亚组。
This study aimed to evaluate differences in plasma and cerebrospinal fluid (CSF) levels of Aβ peptides in older adults with late-life depression compared to non-depressed older controls. We conducted a systematic review and meta-analysis of the literature using PubMed, Web of science and Scopus databases with no search limits for publication dates or languages. Two independent reviewers extracted data and assessed quality. Six hundred references were retrieved, and we included 12 studies in the meta-analysis after eligibility screening. Older adults with late-life depression (LLD) had a higher plasma Aβ40:Aβ42 ratio compared to non-depressed participants (SMD= 1.10, CI95% [0.28; 1.96], p=0.01), and marginally significant reduction of CSF Aβ42 levels (SMD= −1.12, CI95% [−2.47; 0.22], p=0.1). The present results evidence that older adults with depression have significant differences in Aβ metabolism, in the same direction observed in individuals with AD. These differences in the Aβ metabolism may help identify a subgroup of subjects with LLD at higher risk of developing AD.
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人血浆中的β-淀粉样动力学。
影响因子：
--
作者：
Huang Y;Potter R;Sigurdson W;Kasten T;Connors R;Morris JC;Benzinger T;Mintun M;Ashwood T;Ferm M;Budd SL;Bateman RJ
通讯作者：
Bateman RJ
影响因子：
9.3
作者：
Forlenza OV;Diniz BS;Gattaz WF
通讯作者：
Gattaz WF
影响因子：
4
作者：
Hozo SP;Djulbegovic B;Hozo I
通讯作者：
Hozo I
DOI：
10.1176/appi.ajp.2011.10060853
发表时间：
2011-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Aizenstein HJ;Andreescu C;Edelman KL;Cochran JL;Price J;Butters MA;Karp J;Patel M;Reynolds CF 3rd
通讯作者：
Reynolds CF 3rd
影响因子：
3.4
作者：
Benitez, Andreana;Gunstad, John;Murray, Leigh
通讯作者：
Murray, Leigh