How Ebola impacts genetics of Western lowland gorilla populations.
How Ebola impacts genetics of Western lowland gorilla populations.
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DOI：
10.1371/journal.pone.0008375
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发表时间：
2009-12-18
期刊：
影响因子：
3.7
通讯作者：
Ménard N
中科院分区：
文献类型：
--
作者：
Le Gouar PJ;Vallet D;David L;Bermejo M;Gatti S;Levréro F;Petit EJ;Ménard N
野生动物新发传染病是人类健康和生物多样性保护的主要威胁。传染病可能对种群的遗传多样性产生严重后果，这可能增加物种灭绝的可能性。西非和中非的埃博拉疫情导致西部低地大猩猩种群死亡率超过90%。虽然死亡率非常高，但埃博拉病毒对西部低地大猩猩遗传多样性的影响从未得到评估。我们对刚果共和国的三个西部低地大猩猩种群进行了长期研究（奥扎拉-科库阿国家公园、洛西大猩猩保护区都受到埃博拉病毒的影响，而洛西的周边地区没有受到影响）。利用17个微卫星位点，我们比较了人群的遗传多样性和结构，并估计了埃博拉疫情爆发前后的有效规模。尽管在这两个群体的有效大小下降，我们没有检测到损失的遗传多样性后，流行病。我们揭示了最小群体中等位基因频率的时间变化。移民和爆发后的短时间可以解释人口崩溃后遗传多样性的保护。等位基因频率的时间变化不能用遗传漂变或随机抽样来解释。来自基因分化人群的移民和埃博拉病毒引起的非随机死亡，即，选择压力和社会性成本是另一种假设。了解埃博拉病毒对大猩猩遗传动力学的影响对人类健康、灵长类进化和保护生物学至关重要。
Emerging infectious diseases in wildlife are major threats for both human health and biodiversity conservation. Infectious diseases can have serious consequences for the genetic diversity of populations, which could enhance the species' extinction probability. The Ebola epizootic in western and central Africa induced more than 90% mortality in Western lowland gorilla population. Although mortality rates are very high, the impacts of Ebola on genetic diversity of Western lowland gorilla have never been assessed. We carried out long term studies of three populations of Western lowland gorilla in the Republic of the Congo (Odzala-Kokoua National Park, Lossi gorilla sanctuary both affected by Ebola and Lossi's periphery not affected). Using 17 microsatellite loci, we compared genetic diversity and structure of the populations and estimate their effective size before and after Ebola outbreaks. Despite the effective size decline in both populations, we did not detect loss in genetic diversity after the epizootic. We revealed temporal changes in allele frequencies in the smallest population. Immigration and short time elapsed since outbreaks could explain the conservation of genetic diversity after the demographic crash. Temporal changes in allele frequencies could not be explained by genetic drift or random sampling. Immigration from genetically differentiated populations and a non random mortality induced by Ebola, i.e., selective pressure and cost of sociality, are alternative hypotheses. Understanding the influence of Ebola on gorilla genetic dynamics is of paramount importance for human health, primate evolution and conservation biology.
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影响因子：
2.4
作者：
Bermejo, M
通讯作者：
Bermejo, M
DOI：
10.1098/rstb.2001.0900
发表时间：
2001-07-29
影响因子：
6.3
作者：
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通讯作者：
Foufopoulos, J
影响因子：
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作者：
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通讯作者：
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影响因子：
4.9
作者：
Douadi, Melanie I.;Gatti, Sylvain;Petit, Eric J.
通讯作者：
Petit, Eric J.
影响因子：
2.7
作者：
Daszak, P;Cunningham, AA;Hyatt, AD
通讯作者：
Hyatt, AD