Altered Parietal Activation during Non-symbolic Number Comparison in Children with Prenatal Alcohol Exposure.
Altered Parietal Activation during Non-symbolic Number Comparison in Children with Prenatal Alcohol Exposure.
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产前酒精暴露儿童在非符号数字比较过程中顶叶激活发生变化
DOI：
10.3389/fnhum.2017.00627
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发表时间：
2017
影响因子：
2.9
通讯作者：
Meintjes EM
中科院分区：
文献类型：
--
作者：
Woods KJ;Jacobson SW;Molteno CD;Jacobson JL;Meintjes EM
数字处理是一个对产前酒精暴露特别敏感的认知领域，它依赖于完整的顶叶功能。在符号数字处理过程中，顶叶中发现了与酒精相关的大脑激活变化。然而，产前酒精暴露对非符号数字比较的神经相关性和数字距离效应的影响尚未得到研究。使用功能磁共振成像（fMRI），我们检查了在不同难度的非符号数字比较任务中参与数字处理的五个顶叶区域与产前酒精暴露相关的大脑激活差异。提供了 27 名海角色儿童的 fMRI 结果（6 名胎儿酒精综合症 (FAS)/部分 FAS、5 名非综合症重度暴露 (HE)、16 名对照；平均年龄 ± SD = 11.7 ± 1.1 岁）。通过使用时间线回溯法采访母亲来评估胎儿酒精暴露情况。使用具有数量比较和难度级别预测因子的一般线性模型，对五个感兴趣区域、双侧水平顶内沟 (IPS)、双侧后上顶小叶 (PSPL) 和左角回 (左 AG) 中的每一个区域进行单独的受试者分析。提取每个区域每个受试者的每个预测因子的平均信号变化百分比，以检查组差异以及与连续测量酒精暴露的关联。虽然各组在表现上没有差异，但在非符号数字比较中，对照组比暴露儿童更多地激活右侧 PSPL，但在控制母亲吸烟后，这一点并不显着，并且右侧 IPS 比胎儿酒精综合症 (FAS) 或部分 FAS 的儿童更多。随着任务难度的增加，暴露程度较高的儿童会更大程度地募集左侧 AG，这可能是为了部分补偿 PSPL 和 IPS 的功能损伤。值得注意的是，在非综合征性严重暴露儿童中，右侧 PSPL 的激活受到损害，但右侧 IPS 的激活未受影响。这些结果扩展了之前在 FAS/PFAS 的符号数字处理过程中右 IPS 招募不良的发现，表明相对数量的心理表征受到产前酒精暴露对数量的符号和非符号表征的影响。
Number processing is a cognitive domain particularly sensitive to prenatal alcohol exposure, which relies on intact parietal functioning. Alcohol-related alterations in brain activation have been found in the parietal lobe during symbolic number processing. However, the effects of prenatal alcohol exposure on the neural correlates of non-symbolic number comparison and the numerical distance effect have not been investigated. Using functional magnetic resonance imaging (fMRI), we examined differences in brain activation associated with prenatal alcohol exposure in five parietal regions involved in number processing during a non-symbolic number comparison task with varying degrees of difficulty. fMRI results are presented for 27 Cape Colored children (6 fetal alcohol syndome (FAS)/partial FAS, 5 heavily exposed (HE) non-sydromal, 16 controls; mean age ± SD = 11.7 ± 1.1 years). Fetal alcohol exposure was assessed by interviewing mothers using a timeline follow-back approach. Separate subject analyses were performed in each of five regions of interest, bilateral horizontal intraparietal sulci (IPS), bilateral posterior superior parietal lobules (PSPL), and left angular gyrus (left AG), using the general linear model with predictors for number comparison and difficulty level. Mean percent signal change for each predictor was extracted for each subject for each region to examine group differences and associations with continuous measures of alcohol exposure. Although groups did not differ in performance, controls activated the right PSPL more during non-symbolic number comparison than exposed children, but this was not significant after controlling for maternal smoking, and the right IPS more than children with fetal alcohol syndrome (FAS) or partial FAS. More heavily exposed children recruited the left AG to a greater extent as task difficulty increased, possibly to compensate, in part, for impairments in function in the PSPL and IPS. Notably, in non-syndromal heavily exposed children activation was impaired in the right PSPL, but spared in the right IPS. These results extend previous findings of poor right IPS recruitment during symbolic number processing in FAS/PFAS, indicating that mental representation of relative quantity is affected by prenatal alcohol exposure for both symbolic and non-symbolic representations of quantity.
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影响因子：
4.8
作者：
Fan, Jia;Jacobson, Sandra W.;Taylor, Paul A.;Molteno, Christopher D.;Dodge, Neil C.;Stanton, Mark E.;Jacobson, Joseph L.;Meintjes, Ernesta M.
通讯作者：
Meintjes, Ernesta M.
影响因子：
2.5
作者：
Burbaud, P;Camus, O;Allard, M
通讯作者：
Allard, M
DOI：
10.15288/jsa.1975.36.1154
发表时间：
1975-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
BOWMAN, RS;STEIN, LI;NEWTON, JR
通讯作者：
NEWTON, JR
DOI：
10.1097/01.alc.0000156125.50577.ec
发表时间：
2005-03-01
影响因子：
3.2
作者：
Burden, MJ;Jacobson, SW;Jacobson, JL
通讯作者：
Jacobson, JL
影响因子：
4.8
作者：
Fan J;Taylor PA;Jacobson SW;Molteno CD;Gohel S;Biswal BB;Jacobson JL;Meintjes EM
通讯作者：
Meintjes EM