Emerging Role of Mechanical Forces in Cell Fate Acquisition.

Emerging Role of Mechanical Forces in Cell Fate Acquisition.
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DOI:
10.3389/fcell.2022.864522
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发表时间:
2022
影响因子:
5.5
通讯作者:
--
中科院分区:
生物学2区
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--
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机械力现在被认为是关键的细胞效应,它与遗传和细胞信号一起在发育过程中物理地塑造和图案组织和器官。越来越多的努力旨在了解机械力在胚胎发育中控制细胞命运决定的较少探索的作用。在这里,我们讨论最近的例子如何不同的力量反馈到细胞命运规范和组织模式。特别是,我们关注肌动球蛋白收缩力的产生和转导在影响胚胎组织形态发生和细胞命运调节中的作用。
Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of mechanical forces in controlling cell fate decisions in embryonic development. Here we discuss recent examples of how differential forces feedback into cell fate specification and tissue patterning. In particular, we focus on the role of actomyosin-contractile force generation and transduction in affecting tissue morphogenesis and cell fate regulation in the embryo.
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