Polysialic acid expression is not necessary for motor neuron target selectivity.
Polysialic acid expression is not necessary for motor neuron target selectivity.
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DOI：
10.1002/mus.23526
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发表时间：
2013-03
期刊：
影响因子：
3.4
通讯作者：
Madison, Roger D.
中科院分区：
文献类型：
--
作者：
Robinson, Grant A.;Madison, Roger D.
周围神经损伤后的恢复取决于引导轴突回到它们的目标。最近已经提出通过再生轴突来上调聚唾液酸对于这种靶选择性是必要的。我们重新审视了这一命题，使用交叉神经再支配模型，即从闭孔运动神经元，不上调聚唾液酸再生到远端股神经的轴突。我们的目的是评估它们在肌肉和皮肤途径之间的靶向选择性。简单的交叉修复后，闭孔运动神经元没有表现出通路偏好，但同样的修复与缩短皮肤通路导致这些运动神经元选择性靶向肌肉的聚唾液酸非依赖性机制。运动神经元池之间的内在分子差异可以通过操纵它们进入不同的外周神经通路来克服，使得闭孔运动神经元优先投射到肌肉的终末神经分支，尽管不上调聚唾液酸的表达。
Recovery after peripheral nerve lesions depends on guiding axons back to their targets. Polysialic acid upregulation by regrowing axons has been proposed recently as necessary for this target selectivity. We reexamined this proposition using a cross-reinnervation model whereby axons from obturator motor neurons that do not upregulate polysialic acid regenerated into the distal femoral nerve. Our aim was to assess their target selectivity between pathways to muscle and skin. After simple cross-repair, obturator motor neurons showed no pathway preference, but the same repair with a shortened skin pathway resulted in selective targeting of these motor neurons to muscle by a polysialic acid–independent mechanism. The intrinsic molecular differences between motor neuron pools can be overcome by manipulation of their access to different peripheral nerve pathways such that obturator motor neurons preferentially project to a terminal nerve branch to muscle despite not upregulating the expression of polysialic acid.
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影响因子：
16.2
作者：
Garcia, Natalia V. De Marco;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.
影响因子：
--
作者：
ABERCROMBIE, M
通讯作者：
ABERCROMBIE, M
影响因子：
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作者：
Robinson, GA;Madison, RD
通讯作者：
Madison, RD
影响因子：
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作者：
Robinson, GA;Madison, RD
通讯作者：
Madison, RD
影响因子：
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作者：
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通讯作者：
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