Pubertal recalibration of cortisol reactivity following early life parent-child separation.
Pubertal recalibration of cortisol reactivity following early life parent-child separation.
复制标题
早期亲子分离后皮质醇反应性的青春期重新校准
DOI：
10.1016/j.jad.2020.09.030
复制
发表时间：
2020-09
影响因子：
6.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhang DD;Fang J;Zhang L;Yuan JY;Wan YH;Su PY;Tao FB;Sun Y
背景下丘脑-垂体-肾上腺皮质（HPA）轴已被证明可以校准生命早期的逆境，而青春期可能会逆转这种校准。本研究探讨了长期亲子分离对HPA轴反应性的影响以及青春期重新校准假说。方法2019年从中国安徽省池州市农村地区招募了144名年龄8.75至15.25岁（平均年龄12.50岁，SD：1.32）的参与者。从父母那里收集亲子分离的数据。采用自我报告的彼得森青春期发育量表评估青春期成熟度，并使用特里尔儿童社会压力测试测量HPA轴应激反应性。结果对于青春期早期的儿童，童年亲子分离经历与HPA轴反应性减弱相关（B= -1.888，p= 0.034）；而对于青春期后期的儿童，经历过童年早期分离的儿童和没有分离的儿童之间的 HPA 轴反应相似（AUCi:B= -0.426，p= 0.878）。相反，对于经历持续亲子分离的儿童，观察到HPA轴反应性减弱（所有p<0.05）。局限性由于本研究的横截面性质，关于因果关系的结论仍然是推测性的。结论亲子分离对HPA轴失调的影响以时间依赖性方式起作用。这一发现为青春期重新校准假说提供了支持，该假说表明，重点改善青春期环境将有助于那些最初在非支持性条件下长大的人。
BackgroundThe hypothalamic–pituitary–adrenocortical (HPA) axis had been proved to calibrate to early-life adversity and puberty may reverse the calibration. This study examines the consequences of prolonged parent-child separation on HPA axis reactivity and the pubertal recalibration hypothesis.MethodsTotally of 144 participants aged 8.75 to 15.25 (mean age 12.50 years, SD: 1.32) were enrolled from rural areas of Chizhou city, Anhui Province of China in 2019. Data on parent-child separation was collected from parents. Self-reported Peterson Pubertal Development Scale was used to assess pubertal maturation and HPA axis stress reactivity was measured using the Trier Social Stress Test for Children.ResultsFor children at early stage of puberty, childhood parent-child separation experiences were associated with blunted HPA axis reactivity (B= -1.888,p= 0.034); while for those at later stage of puberty, HPA axis reactivity was similar between children experienced early childhood separation and those without separation (AUCi:B= -0.426,p= 0.878). In contrast, for children experienced persistent parent-child separation, blunted HPA axis reactivity was observed (allp< 0.05).LimitationsDue to the cross-sectional nature of this study, conclusions about causality remain speculative.ConclusionsThe effect of parent-child separation on dysregulation of HPA axis acts in a time-dependent manner. This finding provides support for the pubertal recalibration hypothesis suggesting that a focus of improving environment in adolescence would help those individuals reared initially in non-supportive conditions.
登录
查看更多内容
DOI：
10.1111/jcpp.12992
发表时间：
2019-05
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
DePasquale CE;Donzella B;Gunnar MR
通讯作者：
Gunnar MR
DOI：
10.1177/2470547019833647
发表时间：
2019-01-01
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
McEwen, Bruce S
通讯作者：
McEwen, Bruce S
影响因子：
3.5
作者：
Drury SS;Sánchez MM;Gonzalez A
通讯作者：
Gonzalez A
早期亲子分离与端粒长度缩短与青春期心理病理结果之间的关联
影响因子：
3.7
作者：
Chen, Xingxing;Zeng, Chenchen;Sun, Ying
通讯作者：
Sun, Ying
DOI：
10.1037/fam0000309
发表时间：
2017-08
期刊：
Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)
影响因子：
--
作者：
Lawler JM;Koss KJ;Gunnar MR
通讯作者：
Gunnar MR