Behavioral differentiation between itch and pain in mouse.
Behavioral differentiation between itch and pain in mouse.
复制标题
小鼠瘙痒与疼痛之间的行为分化。
DOI：
10.1016/j.pain.2008.08.002
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发表时间：
2008-10-31
期刊：
影响因子：
7.4
通讯作者：
LaMotte RH
中科院分区：
文献类型：
--
作者：
Shimada SG;LaMotte RH
标准的啮齿动物瘙痒模型使用后肢抓挠作为对颈部后缘瘙痒刺激的行为反应。假设抓挠是瘙痒感觉的一个指标。但是因为只有一种部位导向的行为是可用的，所以我们不能确定抓挠不是对除痒之外的伤害性或其他感觉的反应，或者不是对痒的反应。为了扩展模型，我们对小鼠的脸颊进行了化学刺激，并将后肢抓痒作为瘙痒的指标，将前肢擦拭作为疼痛的指标。皮下注射组胺和辣椒素，已知分别在人类中引起瘙痒和疼痛，当注射到小鼠的颈部后颈时，每一种都引起后肢抓痒行为。相比之下，当同样的化学物质注射到老鼠的脸颊时，有两种部位导向的行为：组胺再次引起用后肢抓挠，但辣椒素引起用前肢擦拭。我们得出的结论是，小鼠的“脸颊瘙痒模型”提供了一种化学物质的行为差异，这些化学物质主要引起人类的瘙痒，而那些化学物质则引起伤害性感觉。也就是说，该模型提供了小鼠瘙痒和疼痛之间的行为差异。
The standard rodent model of itch uses scratching with the hind limb as a behavioral response to pruritic stimuli applied to the nape of the neck. The assumption is that scratching is an indicator of the sensation of itch. But because only one type of site-directed behavior is available, one cannot be certain that scratching is not a response to nociceptive or other qualities of sensations in addition to, or instead of, itch. To extend the model, we administered chemical stimuli to the cheek of the mouse and counted scratching with the hind limb as an indicator of itch and wiping with the forelimb as an indicator of pain. An intradermal injection of histamine and capsaicin, known to evoke predominantly itch and pain, respectively, in humans, each elicited hind limb scratching behavior when injected into the nape of the neck of the mouse. In contrast, when the same chemicals were injected into the cheek of the mouse, there were two site-directed behaviors: histamine again elicited scratching with the hind limb, but capsaicin evoked wiping with the forelimb. We conclude that the “cheek model of itch” in the mouse provides a behavioral differentiation of chemicals that elicit predominantly itch in humans from those that evoke nociceptive sensations. That is, the model provides a behavioral differentiation between itch and pain in the mouse.
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影响因子：
7.4
作者：
SIMONE, DA;BAUMANN, TK;LAMOTTE, RH
通讯作者：
LAMOTTE, RH
影响因子：
5
作者：
Shimada, SG;Shimada, KA;Collins, JG
通讯作者：
Collins, JG
影响因子：
5.6
作者：
Minami, K;Kamei, C
通讯作者：
Kamei, C
影响因子：
7.4
作者：
Green, Amanda D.;Young, Katrina K.;Mogil, Jeffrey S.
通讯作者：
Mogil, Jeffrey S.
DOI：
10.1159/000056338
发表时间：
2001-03-01
期刊：
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
影响因子：
--
作者：
Inagaki, N;Nagao, M;Nagai, H
通讯作者：
Nagai, H