Noun and verb processing in aphasia: Behavioural profiles and neural correlates.
Noun and verb processing in aphasia: Behavioural profiles and neural correlates.
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DOI：
10.1016/j.nicl.2018.01.023
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lambon Ralph MA
中科院分区：
文献类型：
--
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
支持不同词类（尤其是名词和动词）的行为和神经过程一直是心理语言学、神经心理学和失语学研究的长期关注领域。该主题具有关于语言系统组织的理论意义，以及与语言缺陷患者的管理相关的临床后果。然而，研究结果存在很大分歧，这可能部分反映了方法论差异，特别是与控制名词和动词之间的心理语言差异有关。因此，这项研究的首要目标是开发一套神经心理学测试，评估单词的产生和对一组匹配的名词和动词的理解。其次，基于这些新颖的测试，在一个由 48 名慢性中风后失语症患者组成的相对较大的队列中，探索了名词和动词处理的行为特征和神经相关性。数据驱动的方法，主成分分析（PCA），也被用来确定名词和动词的产生和理解与患者潜在的基本语言领域的关系。结果显示，一旦在多种心理语言学特征（包括最关键的可形象性）上匹配，名词和动词的产生和理解之间就没有表现差异。有趣的是，一旦使用了不匹配的材料，先前研究中发现的名词-动词差异在本研究中得到了复制。病变症状映射揭示了沿左颞叶和顶叶区域名词和动词处理的重叠神经关联。这些发现支持这样的观点：单词级别的名词和动词处理的神经表征是由分布式皮质区域共同支持的。 PCA 产生了失语症的五个基本语言和认知成分：语音产生、语音识别、语义、流畅性和执行功能。与行为分析和病变症状映射结果一致，名词和动词处理都加载在共同的基础语言域上：语音产生和语义。这五个主要组成部分的神经相关性与现有的语言模型以及功能性神经成像和神经刺激等其他技术所涉及的区域一致。开发了一组新的匹配的名词和动词来评估命名和理解。一旦在多个心理语言特征上匹配，就没有名词-动词处理差异。名词和动词处理的神经关联在皮层内共同支持。中风失语症是由独立但互动的语言域调节的。核心语言功能由灰质和白质区域支持。
The behavioural and neural processes underpinning different word classes, particularly nouns and verbs, have been a long-standing area of interest in psycholinguistic, neuropsychology and aphasiology research. This topic has theoretical implications concerning the organisation of the language system, as well as clinical consequences related to the management of patients with language deficits. Research findings, however, have diverged widely, which might, in part, reflect methodological differences, particularly related to controlling the psycholinguistic variations between nouns and verbs. The first aim of this study, therefore, was to develop a set of neuropsychological tests that assessed single-word production and comprehension with a matched set of nouns and verbs. Secondly, the behavioural profiles and neural correlates of noun and verb processing were explored, based on these novel tests, in a relatively large cohort of 48 patients with chronic post-stroke aphasia. A data-driven approach, principal component analysis (PCA), was also used to determine how noun and verb production and comprehension were related to the patients' underlying fundamental language domains. The results revealed no performance differences between noun and verb production and comprehension once matched on multiple psycholinguistic features including, most critically, imageability. Interestingly, the noun-verb differences found in previous studies were replicated in this study once un-matched materials were used. Lesion-symptom mapping revealed overlapping neural correlates of noun and verb processing along left temporal and parietal regions. These findings support the view that the neural representation of noun and verb processing at single-word level are jointly-supported by distributed cortical regions. The PCA generated five fundamental language and cognitive components of aphasia: phonological production, phonological recognition, semantics, fluency, and executive function. Consistent with the behavioural analyses and lesion-symptom mapping results, both noun and verb processing loaded on common underlying language domains: phonological production and semantics. The neural correlates of these five principal components aligned with existing models of language and the regions implicated by other techniques such as functional neuroimaging and neuro-stimulation. Developed new matched set of nouns and verbs to assess naming and comprehension. No noun-verb processing differences once matched on multiple psycholinguistic features. Neural correlates of noun and verb processing jointly supported within the cortex. Stroke aphasia is modulated by independent but interactive language domains. Core language functions are supported by grey and white matter regions.
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DOI：
10.1016/j.nicl.2017.12.009
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
DOI：
10.1073/pnas.90.11.4957
发表时间：
1993-06-01
影响因子：
11.1
作者：
DAMASIO, AR;TRANEL, D
通讯作者：
TRANEL, D
DOI：
10.1093/brain/awu286
发表时间：
2014-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Butler RA;Lambon Ralph MA;Woollams AM
通讯作者：
Woollams AM
影响因子：
2
作者：
Bastiaanse, R;Jonkers, R
通讯作者：
Jonkers, R
影响因子：
11.2
作者：
Catani, M;Jones, DK;Ffytche, DH
通讯作者：
Ffytche, DH