Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation.

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation.
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DOI:
10.1038/s41593-018-0171-8
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发表时间:
2018-07
影响因子:
25
通讯作者:
Srinivasan R
Srinivasan R
中科院分区:
医学1区
文献类型:
--
作者:
Pesaran B;Vinck M;Einevoll GT;Sirota A;Fries P;Siegel M;Truccolo W;Schroeder CE;Srinivasan R

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New technologies to record electrical activity from the brain on a massive scale offer tremendous opportunities for discovery. Electrical measurements of large-scale brain dynamics, termed field potentials, are especially important to understanding and treating the human brain. Here, our goal is to provide best practices on how field potential recordings (electroencephalograms, magnetoencephalograms, electrocorticograms and local field potentials) can be analyzed to identify large-scale brain dynamics, and to highlight critical issues and limitations of interpretation in current work. We focus our discussion of analyses around the broad themes of activation, correlation, communication and coding. We provide recommendations for interpreting the data using forward and inverse models. The forward model describes how field potentials are generated by the activity of populations of neurons. The inverse model describes how to infer the activity of populations of neurons from field potential recordings. A recurring theme is the challenge of understanding how field potentials reflect neuronal population activity given the complexity of the underlying brain systems.
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