Patterning of the Drosophila retina by the morphogenetic furrow.
Patterning of the Drosophila retina by the morphogenetic furrow.
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DOI：
10.3389/fcell.2023.1151348
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
图案形成是同质上皮片中的细胞根据它们彼此之间的相对空间位置获得不同命运的过程。从艾伦·图灵的扩散-反应模型开始，在过去的70多年里，人们提出了几个建议，以描述脊椎动物体节和皮毛、哺乳动物臼齿、鱼鳞和鸟类羽芽等周期模式是如何在发育过程中出现的。测试上述模型并识别控制图案形成的基因调控网络的最佳实验系统之一是果蝇的复眼。一个多世纪以来，人们对其细胞形态发生进行了广泛的研究，并分离出了数百种影响其发育的突变体。在这篇综述中，我们将重点关注形态发生沟，这是一种分化波，它将最初均匀的细胞片转化为单位眼或小眼的有序阵列。自从1976年发现沟槽以来，人们一直认为正负作用的形态因子是使沟槽在一片静止的细胞场中传播的唯一原因。然而，最近的一项研究对这一模型提出了挑战，提出机械驱动的细胞流也有助于视网膜图案的形成。我们将讨论这两种模型及其对图案化的影响。
Pattern formation is the process by which cells within a homogeneous epithelial sheet acquire distinctive fates depending upon their relative spatial position to each other. Several proposals, starting with Alan Turing’s diffusion-reaction model, have been put forth over the last 70 years to describe how periodic patterns like those of vertebrate somites and skin hairs, mammalian molars, fish scales, and avian feather buds emerge during development. One of the best experimental systems for testing said models and identifying the gene regulatory networks that control pattern formation is the compound eye of the fruit fly, Drosophila melanogaster. Its cellular morphogenesis has been extensively studied for more than a century and hundreds of mutants that affect its development have been isolated. In this review we will focus on the morphogenetic furrow, a wave of differentiation that takes an initially homogeneous sheet of cells and converts it into an ordered array of unit eyes or ommatidia. Since the discovery of the furrow in 1976, positive and negative acting morphogens have been thought to be solely responsible for propagating the movement of the furrow across a motionless field of cells. However, a recent study has challenged this model and instead proposed that mechanical driven cell flow also contributes to retinal pattern formation. We will discuss both models and their impact on patterning.
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影响因子：
3.7
作者：
Won JH;Tsogtbaatar O;Son W;Singh A;Choi KW;Cho KO
通讯作者：
Cho KO
影响因子：
2.6
作者：
BAKER, NE;ZITRON, AE
通讯作者：
ZITRON, AE
影响因子：
10.5
作者：
CAGAN, RL;READY, DF
通讯作者：
READY, DF
DOI：
10.1007/bf00848423
发表时间：
1977-01-01
期刊：
WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY
影响因子：
--
作者：
CAMPOSORTEGA, JA;HOFBAUER, A
通讯作者：
HOFBAUER, A
影响因子：
64.5
作者：
BONINI, NM;LEISERSON, WM;BENZER, S
通讯作者：
BENZER, S