Ten putative contributors to the obesity epidemic.
Ten putative contributors to the obesity epidemic.
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DOI：
10.1080/10408390903372599
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发表时间：
2009-11
影响因子：
10.2
通讯作者：
Allison DB
中科院分区：
文献类型：
--
作者：
McAllister EJ;Dhurandhar NV;Keith SW;Aronne LJ;Barger J;Baskin M;Benca RM;Biggio J;Boggiano MM;Eisenmann JC;Elobeid M;Fontaine KR;Gluckman P;Hanlon EC;Katzmarzyk P;Pietrobelli A;Redden DT;Ruden DM;Wang C;Waterland RA;Wright SM;Allison DB
肥胖症流行是一个全球性问题，并没有显示出减弱的迹象，而这种流行病的原因仍然不清楚。高能量食品的营销做法和体制驱动的体力活动减少被指控是这一流行病的肇事者，尽管缺乏确凿的证据证明其因果作用。虽然两者都可能导致肥胖，但我们提请注意它们在减少肥胖的项目资金和公共努力中毫无疑问的主导地位，并提出了几个替代的假定贡献者，这些贡献者将从平等的考虑和关注中受益。本文综述了微生物、表观遗传学、母亲年龄的增加、肥胖症患者的生育力增加、强迫交配、睡眠债、内分泌干扰物、药物医源性、环境温度变化的减少以及宫内和代际效应等肥胖流行的影响因素。虽然证据是强有力的一些贡献者，如药物引起的体重增加，它仍然是新兴的其他审查因素。考虑到这些假定的肥胖病因的作用，可能会导致全面的，具体的原因，和有效的战略，预防和治疗这一全球流行病。
The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects, as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors. Considering the role of such putative etiological factors of obesity may lead to comprehensive, cause specific, and effective strategies for prevention and treatment of this global epidemic.
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影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
16.2
作者：
Ayas, NT;White, DP;Hu, FB
通讯作者：
Hu, FB
影响因子：
7.7
作者：
Barker, DJP;Eriksson, JG;Osmond, C
通讯作者：
Osmond, C
影响因子：
2.9
作者：
Artiga, A. I.;Viana, J. B.;Boggiano, M. M.
通讯作者：
Boggiano, M. M.
影响因子：
5.1
作者：
Bastian, LA;West, NA;Munger, RG
通讯作者：
Munger, RG