Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects.
Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects.
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MMP2-1306 C/T 多态性与前列腺癌易感性之间的关联：基于 3906 名受试者的荟萃分析
DOI：
10.18632/oncotarget.16972
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发表时间：
2017-07-04
期刊：
影响因子：
--
通讯作者：
Liang C
中科院分区：
文献类型：
--
作者：
Zhang K;Chen X;Zhou J;Yang C;Zhang M;Chao M;Zhang L;Liang C
许多研究已经探讨了 MMP2-1306C/T 多态性与前列腺癌 (PCa) 易感性之间的相关性。然而，这些结论存在争议。因此，我们基于截至 2016 年 10 月 21 日来自 PubMed、Embase、Cochrane Library、中国生物医学光盘 (CBM)、中国知网 (CNKI) 的六项研究进行了本次荟萃分析。计算了比值比 (OR) 和 95% 置信区间 (CI)，以评估相关性的强度。此外，还进行了不同的亚组分析和发表偏倚测试。最终，之前的 6 项调查（包括 1920 个病例和 1986 个对照）被确定并纳入本荟萃分析。因此，我们的证据表明，MMP2-1306C/T 多态性与总体人群中的 PCa 风险之间存在一定的关联（T 与 C：OR = 1.12，95% CI = 1.00-1.24，P = 0.040；TT+CT 与 CC：OR = 1.16，95% CI = 1.02-1.32，P = 0.026），以及亚洲人群亚组（分别为 T vs C：OR=1.48，95% CI=1.13-1.94，P=0.004；TT+CT vs CC：OR = 1.66，95% CI = 1.21-2.28，P = 0.002）和 PCR-RFLP 基因分型方法（T vs C：OR = 1.58，95% CI = 1.19-2.10，P = 0.001；TT+CT 与 CC：OR = 1.71，95% CI = 1.23-2.38，P = 0.001；然而，未检测到 MMP2-1306C/T 多态性与 PCa 的 Gleason 分级或病理分期相关。我们的研究表明 MMP2-1306 C/T 多态性可能会增加 PCa 风险，特别是对于亚洲人群。然而，未来需要包括来自多中心的大队列研究来证实我们的结论。
Numerous investigations have addressed the correlation between MMP2-1306C/T polymorphism and prostate cancer (PCa) susceptibility. However, these conclusions were controversial. Thus, we conducted this current meta-analysis based on six studies from PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI) up to October 21st, 2016. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations. Additionally, different subgroup analyses and publication bias tests were performed. Eventually, six previous investigations consisted of 1920 cases and 1986 controls were identified and involved in this meta-analysis. Consequently, our evidence indicates a certain association between MMP2-1306C/T polymorphism and PCa risk among overall population (T vs C: OR = 1.12, 95% CI = 1.00-1.24, P = 0.040; TT+CT vs CC: OR = 1.16, 95% CI = 1.02-1.32, P = 0.026; respectively), as well as the subgroups of Asian population (T vs C: OR=1.48, 95% CI=1.13-1.94, P=0.004; TT+CT vs CC: OR = 1.66, 95% CI = 1.21-2.28, P = 0.002; respectively) and PCR-RFLP genotyped method (T vs C: OR = 1.58, 95% CI = 1.19-2.10, P = 0.001; TT+CT vs CC: OR = 1.71, 95% CI = 1.23-2.38, P = 0.001; respectively). However, no association was detected in MMP2-1306C/T polymorphism with Gleason grading or pathological stage of PCa. Our study indicates MMP2-1306 C/T polymorphism might increase PCa risk, particularly for Asian population. However, future studies comprising large cohort size from multicenter are required to confirm our conclusions.
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影响因子：
3.5
作者：
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DOI：
10.1016/0197-2456(86)90046-2
发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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