Microfluidics-assisted in vitro drug screening and carrier production.
Microfluidics-assisted in vitro drug screening and carrier production.
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DOI：
10.1016/j.addr.2013.07.004
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发表时间：
2013-11
影响因子：
16.1
通讯作者：
Kim, Deok-Ho
中科院分区：
文献类型：
--
作者：
Tsui, Jonathan H.;Lee, Woohyuk;Pun, Suzie H.;Kim, Jungkyu;Kim, Deok-Ho
微流控平台为药物开发提供了几个独特的优势。在药物载体的生产中，通过调节流速和几何形状，可以简单而有效地改变尺寸和形状等物理性质和药物组成和药代动力学参数等化学性质。然后，可以用最小的努力制造大量的载体，并且几乎没有批次之间的差异。此外，微流控系统中的细胞或组织培养模型可用作体外药物筛选工具。与活体动物模型相比，微流控药物筛选平台能够以显著较低的成本实现高通量和可重复性的筛选，并且当与当前组织工程的进展相结合时，也能够模拟天然组织。本文综述了用于药物和基因载体制备的各种微流控平台，为设计合适的载体提供指导。还对用于高通量分析和体内条件复制的体外微流控药物筛选平台进行了综述，以强调未来药物研究和开发的方向。
Microfluidic platforms provide several unique advantages for drug development. In the production of drug carriers, physical properties such as size and shape, and chemical properties such as drug composition and pharmacokinetic parameters, can be modified simply and effectively by tuning the flow rate and geometries. Large numbers of carriers can then be fabricated with minimal effort and with little to no batch-to-batch variation. Additionally, cell or tissue culture models in microfluidic systems can be used as in vitro drug screening tools. Compared to in vivo animal models, microfluidic drug screening platforms allow for high-throughput and reproducible screening at a significantly lower cost, and when combined with current advances in tissue engineering, are also capable of mimicking native tissues. In this review, various microfluidic platforms for drug and gene carrier fabrication are reviewed to provide guidelines for designing appropriate carriers. In vitro microfluidic drug screening platforms designed for high-throughput analysis and replication of in vivo conditions are also reviewed to highlight future directions for drug research and development.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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