Postnatal development of layer III pyramidal cells in the primary visual, inferior temporal, and prefrontal cortices of the marmoset.
Postnatal development of layer III pyramidal cells in the primary visual, inferior temporal, and prefrontal cortices of the marmoset.
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DOI：
10.3389/fncir.2013.00031
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发表时间：
2013
影响因子：
3.5
通讯作者：
Ichinohe N
中科院分区：
文献类型：
--
作者：
Oga T;Aoi H;Sasaki T;Fujita I;Ichinohe N
树突棘生成和/或修剪过程的异常与包括自闭症和精神分裂症在内的多种精神疾病有关。我们选择将普通狨猴（Callithrix jacchus）作为灵长类动物模型来探索这一过程。作为第一步，我们研究了初级视觉感觉皮层（V1）、视觉关联皮层（颞下区，TE）和前额叶皮层（12区，PFC）的基底树突树和第三层锥体细胞棘的出生后发育。与新生儿相比，成年期所有三个区域的基底树突都更长。特别是，在产后第二个月左右，TE 和 PFC 中都出现了快速的树突生长。这种早期的生长突增导致 TE 和 PFC 中的树突乔木比 V1 中的大得多。沿着树突的棘密度在 3 个月大时达到峰值，随后在所有三个区域中均下降：V1 中的棘修剪程度大于 TE 和 PFC。在整个发育过程中，对单个锥体细胞基底树突中棘总数的估计在 TE 和 PFC 中大于 V1，并且在所有三个区域中出生后 3 个月左右达到峰值。这些棘和树突的发育概况将有助于确定用于筛选参与狨猴皮层中棘发生和修剪的分子的分析点。
Abnormalities in the processes of the generation and/or pruning of dendritic spines have been implicated in several mental disorders including autism and schizophrenia. We have chosen to examine the common marmoset (Callithrix jacchus) as a primate model to explore the processes. As a first step, we studied the postnatal development of basal dendritic trees and spines of layer-III pyramidal cells in the primary visual sensory cortex (V1), a visual association cortex (inferior temporal area, TE), and a prefrontal cortex (area 12, PFC). Basal dendrites in all three areas were longer in adulthood compared with those in the newborn. In particular, rapid dendritic growth occurred in both TE and PFC around the second postnatal month. This early growth spurt resulted in much larger dendritic arbors in TE and PFC than in V1. The density of the spines along the dendrites peaked at 3 months of age and declined afterwards in all three areas: the degree of spine pruning being greater in V1 than in TE and PFC. The estimates of the total numbers of spines in the basal dendrites of a single pyramidal cell were larger in TE and PFC than in V1 throughout development and peaked around 3 months after birth in all three areas. These developmental profiles of spines and dendrites will help in determining assay points for the screening of molecules involved in spinogenesis and pruning in the marmoset cortex.
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作者：
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通讯作者：
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通讯作者：
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