Bite-size introduction to canine hematologic malignancies.
Bite-size introduction to canine hematologic malignancies.
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DOI：
10.1182/bloodadvances.2021005045
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发表时间：
2022-07-12
期刊：
影响因子：
7.5
通讯作者：
Mason, Nicola J.
中科院分区：
文献类型：
--
作者：
Atherton, Matthew J.;Mason, Nicola J.
恶性血液病经常在狗身上被诊断出来，并导致与特定疾病类型相关的一系列临床症状。犬最常见的血液肿瘤包括淋巴瘤、淋巴细胞性和髓系白血病，以及肥大细胞、浆细胞和组织细胞肿瘤。再加上不同类别和不同亚型的犬恶性血液病的不同表现，这些肿瘤的结果也是不同的。考虑到这一点，适当的治疗选择范围从积极监测到治疗意图方法，利用手术、化疗和基于放射的方式。其中许多疾病的基本病理与人类患者的相应诊断有惊人的相似之处。我们介绍了一些犬类血液病的致病因素，以及它们的临床表现。还提供了针对每种疾病的标准护理疗法的概述。随着比较肿瘤学被认为是研究肿瘤发病机制并为评估新疗法提供强大的、临床相关的、免疫活性模型的有价值的环境，参与涉及狗的癌症研究的临床医生和科学家的数量预计将增加。本综述旨在提供犬恶性血液病的介绍性概述。
Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most frequently encountered hematologic tumors in dogs include lymphoma, lymphoid and myeloid leukemias, and mast cell, plasma cell, and histiocytic neoplasias. Coupled with the heterogeneous presentations of the different categories and subtypes of canine hematologic malignancies, outcomes for these tumors are also variable. Considering this, appropriate treatment options range from active surveillance to curative intent approaches harnessing surgical, chemotherapeutic, and radiation-based modalities. The underlying pathology of many of these diseases bears remarkable resemblance to that of the corresponding diagnosis made in human patients. We introduce some of the pathogenic drivers of canine hematologic cancers alongside their clinical presentations. An overview of standard-of-care therapies for each of these diseases is also provided. As comparative oncology gains recognition as a valuable setting in which to investigate the pathogenesis of neoplasia and provide powerful, clinically relevant, immunocompetent models for the evaluation of novel therapies, the number of clinicians and scientists participating in cancer research involving dogs is expected to increase. This review aims at providing an introductory overview of canine hematologic malignancies.
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