Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation.
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation.
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DOI：
10.1126/sciadv.abj0153
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发表时间：
2021-08
期刊：
影响因子：
13.6
通讯作者：
Guan J
中科院分区：
文献类型：
--
作者：
Guan Y;Niu H;Liu Z;Dang Y;Shen J;Zayed M;Ma L;Guan J
氧气的持续释放通过调节上皮形成、血管生成和炎症来加速糖尿病伤口愈合。糖尿病伤口不愈合是糖尿病患者常见的并发症。由于慢性缺氧显著延迟伤口愈合，因此假设持续充氧以缓解缺氧可促进糖尿病伤口愈合。然而，目前的临床方法，包括高压氧治疗，不能实现持续的氧合。在这里，我们提出了一个持续的氧合系统组成的氧释放微球和活性氧（ROS）清除水凝胶。水凝胶捕获糖尿病伤口中自然升高的ROS，其可以通过从施用的微球释放的氧进一步升高。氧的持续释放增强了角质形成细胞和真皮成纤维细胞的存活和迁移，促进了血管生成生长因子的表达和糖尿病伤口中的血管生成，并降低了促炎细胞因子的表达。这些作用显著增加了伤口闭合率。我们的研究结果表明，持续的氧合，而不使用药物，可以治愈糖尿病伤口。
Sustained release of oxygen accelerates diabetic wound healing by regulating epithelialization, angiogenesis, and inflammation. Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. However, sustained oxygenation cannot be achieved by current clinical approaches, including hyperbaric oxygen therapy. Here, we present a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)–scavenging hydrogel. The hydrogel captures the naturally elevated ROS in diabetic wounds, which may be further elevated by the oxygen released from the administered microspheres. The sustained release of oxygen augmented the survival and migration of keratinocytes and dermal fibroblasts, promoted angiogenic growth factor expression and angiogenesis in diabetic wounds, and decreased the proinflammatory cytokine expression. These effects significantly increased the wound closure rate. Our findings demonstrate that sustained oxygenation alone, without using drugs, can heal diabetic wounds.
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