Auditory sensory memory in schizophrenia: inadequate trace formation?

Auditory sensory memory in schizophrenia: inadequate trace formation?
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精神分裂症的听觉感觉记忆:痕迹形成不足?

DOI:
10.1016/s0165-1781(00)00205-5
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发表时间:
2000
影响因子:
11.3
通讯作者:
A. Jablensky
A. Jablensky
中科院分区:
医学2区
文献类型:
--
作者:
J. Todd;P. Michie;T. Budd;D. Rock;A. Jablensky

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本研究探讨了持续时间不匹配的负性减少观察到的精神分裂症患者,特别是时间歧视和两个事件相关电位(ERP)组件发生在听觉感觉记忆的第一阶段的行为措施的关系。22名DSM-IV和ICD-10诊断为精神分裂症的患者和25名健康对照志愿者参加了行为和ERP测试。两组在填充间期持续时间辨别和间隙检测的行为估计上表现相当。与此相反,电生理测量显示,患者的持续时间不匹配的负性显着减少,患者的N100促进模式在短刺激发作的神经元上有显着差异。虽然行为的结果表明完整的时间处理的填充间隔和相等的时间分辨率限制精神分裂症,两个ERP措施表明听觉处理的差异,可以追溯到活动发生在第一个250毫秒。结果突出的可能性异常的过程中,精神分裂症的听觉痕迹的形成和时间的总和。
This study explored duration mismatch negativity reductions observed in individuals with schizophrenia, in particular, the relationship to behavioural measures of temporal discrimination and two event-related potential (ERP) components occurring during the first phase of auditory sensory memory. Twenty-two patients with a DSM-IV and ICD-10 diagnosis of schizophrenia and 25 healthy comparison volunteers participated in a behavioural and an ERP testing session. Both groups performed equivalently on behavioural estimates of filled interval duration discrimination and gap detection. In contrast, electrophysiological measures revealed a significant reduction in patients’ duration mismatch negativity and a significant difference in patients for the pattern of N100 facilitation over short stimulus onset asynchronies. Whilst behavioural results indicate intact temporal processing of filled intervals and equal temporal resolution limits in schizophrenia, both ERP measures indicated differences in auditory processing that may be traced to activity occurring during the first 250 ms. Results highlight the possibility of abnormalities in the process of auditory trace formation and temporal summation in schizophrenia.
DOI: 10.1111/j.1469-8986.1993.tb03209.x
发表时间: 1993-01-01
期刊: PSYCHOPHYSIOLOGY
影响因子: 3.7
作者:
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通讯作者: WOLDORFF, MG
DOI: 10.1176/ajp.152.10.1517
发表时间: 1995-10
期刊: The American journal of psychiatry
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DOI: 10.1037/0097-7403.9.2.171
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DOI: 10.1016/0013-4694(94)00173-1
发表时间: 1994-11-01
期刊: ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子: --
作者:
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通讯作者: NAATANEN, R