Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation.
Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation.
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DOI：
10.1016/j.polymdegradstab.2011.06.005
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发表时间：
2011-09-01
影响因子：
5.9
通讯作者：
Uhrich, Kathryn E.
中科院分区：
文献类型：
--
作者：
Rosario-Melendez, Roselin;Lavelle, Linda;Bodnar, Stanko;Halperin, Frederick;Harper, Ike;Griffin, Jeremy;Uhrich, Kathryn E.
通过将聚合物暴露于0（对照）、25和50 kGy，研究了电子束和γ辐射对基于水杨酸酯的聚（酸酐-酯）的物理化学性质的影响。辐射暴露后，监测水杨酸体外释放以评估药物释放曲线的任何变化。分子量，玻璃化转变温度和分解温度进行了评价聚合物断链和/或交联以及热性能的变化。质子核磁共振和红外光谱也被用来确定聚合物降解和/或断链。进行体外细胞研究以鉴定辐射暴露后的细胞相容性。这些研究表明，聚合物的物理化学性质基本上不受暴露于电子束和伽马辐射的影响。
The effect of electron beam and gamma radiation on the physicochemical properties of a salicylate-based poly(anhydride-ester) was studied by exposing polymers to 0 (control), 25 and 50 kGy. After radiation exposure, salicylic acid release in vitro was monitored to assess any changes in drug release profiles. Molecular weight, glass transition temperature and decomposition temperature were evaluated for polymer chain scission and/or crosslinking as well as changes in thermal properties. Proton nuclear magnetic resonance and infrared spectroscopies were also used to determine polymer degradation and/or chain scission. In vitro cell studies were performed to identify cytocompatibility following radiation exposure. These studies demonstrate that the physicochemical properties of the polymer are not substantially affected by exposure to electron beam and gamma radiation.
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影响因子：
3.2
作者：
Schmeltzer, RC;Anastasiou, TJ;Uhrich, KE
通讯作者：
Uhrich, KE
影响因子：
14
作者：
Edlund, U;Albertsson, AC;Lundgren, BO
通讯作者：
Lundgren, BO
影响因子：
2.4
作者：
Rosenberg, L. E.;Carbone, A. L.;Chikindas, M. L.
通讯作者：
Chikindas, M. L.
影响因子：
1.7
作者：
Schmeltzer, RC;Uhrich, KE
通讯作者：
Uhrich, KE
影响因子：
4.9
作者：
Whitaker-Brothers, K;Uhrich, K
通讯作者：
Uhrich, K