A chitosan-modified graphene nanogel for noninvasive controlled drug release.
A chitosan-modified graphene nanogel for noninvasive controlled drug release.
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DOI：
10.1016/j.nano.2013.01.003
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发表时间：
2013-10
影响因子：
5.4
通讯作者：
Mohapatra, Subhra
中科院分区：
文献类型：
--
作者：
Wang, Chunyan;Mallela, Jaya;Garapati, Ujjwala Sree;Ravi, Sowndharya;Chinnasamy, Vignesh;Girard, Yvonne;Howell, Mark;Mohapatra, Subhra
A near infrared (NIR) triggered drug delivery platform based on the chitosan-modified chemically reduced graphene oxide (CRGO) incorporated into a thermosensitive nanogel (CGN) was developed. CGN exhibited an NIR-induced thermal effect similar to that of CRGO, reversible thermo-responsive characteristics at 37–42 °C and high doxorubicin hydrochloride (DOX) loading capacity (48 wt%). The DOX loaded CGN (DOX-CGN) released DOX faster at 42 °C than at 37 °C. The fluorescence images revealed DOX expression in the cytoplasm of cancer cells when incubated with DOX-CGN at 37 °C but in the nucleus at 42 °C. Upon irradiation with NIR light (808 nm), a rapid, repetitive DOX release from the DOX-CGN was observed. Furthermore, the cancer cells incubated with DOX-CGN and irradiated with NIR light displayed significantly greater cytotoxicity than without irradiation owing to NIR-triggered increase in temperature leading to nuclear DOX release. These results demonstrate CGN’s promising application for on-demand drug release by NIR light.
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