Virulence factors for hemolytic uremic syndrome, Denmark.

Virulence factors for hemolytic uremic syndrome, Denmark.
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DOI:
10.3201/eid1005.030576
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发表时间:
2004-05
影响因子:
11.8
通讯作者:
Mølbak K
Mølbak K
中科院分区:
医学2区
文献类型:
--
作者:
Ethelberg S;Olsen KE;Scheutz F;Jensen C;Schiellerup P;Enberg J;Petersen AM;Olesen B;Gerner-Smidt P;Mølbak K

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我们提出了一个分析菌株和患者的因素与发展中的出血性腹泻和溶血性尿毒综合征(HUS)的滋贺产毒素大肠杆菌(STEC)患者在丹麦在6年的时间内注册。在343例STEC患者中,36.4%发生血性腹泻,6.1%发生HUS。在多变量logistic回归模型中,血性腹泻的危险因素是eae和stx2基因,O型O157和O103,以及年龄增加。HUS的风险因素包括stx 2(比值比[OR] 18.9)和eae(OR未定义)基因的存在、儿童和有血腥腹泻。O组O157虽然在单变量分析中与HUS相关(OR 4.0),但在多变量分析中不相关(OR 1.1)。这一发现表明,而不是O组,eae和stx2基因的组合存在是HUS的重要预测因子。
We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.
DOI: 10.1128/jcm.37.7.2312-2316.1999
发表时间: 1999-07-01
影响因子: 9.4
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