Facile and efficient preparation of anisotropic DNA-functionalized gold nanoparticles and their regioselective assembly.
Facile and efficient preparation of anisotropic DNA-functionalized gold nanoparticles and their regioselective assembly.
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DOI：
10.1021/ja408033e
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发表时间：
2013-11-27
影响因子：
15
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Tan LH;Xing H;Chen H;Lu Y
Anisotropic nanoparticles can provide considerable opportunities for assembly of nanomaterials with unique structures and properties. However, most reported anisotropic nanoparticles are either difficult to prepare, have a low yield, or difficult to functionalize. Here we report a facile one-step solution-based method to prepare anisotropic DNA-functionalized gold nanoparticles (a-DNA-AuNP) with 96% yield and with high DNA density (120 ± 20 strands on the gold hemisphere surface). The method is based on the competition between a thiolated hydrophilic DNA and a thiolated hydrophobic phospholipid and has been applied to prepare a-DNA-AuNP with different sizes of nanoparticles and a variety of DNA sequences. In addition, DNA strands on the a-DNA-AuNP can be exchanged with other DNA strands with a different sequence. The anisotropic nature of the a-DNA-AuNPs allows regioselective hetero- and homo-nuclear assembly with high monodispersity, as well as regioselective functionalization of two different DNA strands for more diverse applications.
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