Postnatal Innate Immune Development: From Birth to Adulthood.
Postnatal Innate Immune Development: From Birth to Adulthood.
复制标题
DOI：
10.3389/fimmu.2017.00957
复制
发表时间：
2017
影响因子：
7.3
通讯作者：
Papadopoulos NG
中科院分区：
文献类型：
--
作者：
Georgountzou A;Papadopoulos NG
众所周知，生命早期适应性免疫反应存在缺陷，导致死亡率和发病率增加。先天免疫不同组成部分的发展轨迹直到最近才被探索。不同区室/解剖部位内的单个分子、细胞或先天识别和信号传导途径表现出不同的成熟模式。尽管已发表的数据存在一些差异，但有价值的信息正在出现，表明生命早期细胞因子反应的发育模式是年龄和Toll样受体特异性的，并且可能受到遗传和环境因素的影响。有趣的是，特定的环境暴露与先天功能改变和慢性炎症性疾病（例如呼吸道过敏）的发生有关。随着这些情况的增加，我们需要扩大对先天免疫发育及其调节因素的了解。更好地了解与疾病发作和持续相关的事件顺序将有助于采取有意义的干预措施。这篇综述描述了正常出生后先天免疫个体发育的最新技术，并重点介绍了目前正在探索或应该进一步解决的研究领域。
It is well established that adaptive immune responses are deficient in early life, contributing to increased mortality and morbidity. The developmental trajectories of different components of innate immunity are only recently being explored. Individual molecules, cells, or pathways of innate recognition and signaling, within different compartments/anatomical sites, demonstrate variable maturation patterns. Despite some discrepancies among published data, valuable information is emerging, showing that the developmental pattern of cytokine responses during early life is age and toll-like receptor specific, and may be modified by genetic and environmental factors. Interestingly, specific environmental exposures have been linked both to innate function modifications and the occurrence of chronic inflammatory disorders, such as respiratory allergies. As these conditions are on the rise, our knowledge on innate immune development and its modulating factors needs to be expanded. Improved understanding of the sequence of events associated with disease onset and persistence will lead toward meaningful interventions. This review describes the state-of-the-art on normal postnatal innate immune ontogeny and highlights research areas that are currently explored or should be further addressed.
登录
查看更多内容
影响因子：
3.8
作者：
Aittoniemi, J;Miettinen, A;Soppi, E
通讯作者：
Soppi, E
DOI：
10.1016/j.clim.2009.07.003
发表时间：
2009-11
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Belderbos ME;van Bleek GM;Levy O;Blanken MO;Houben ML;Schuijff L;Kimpen JL;Bont L
通讯作者：
Bont L
影响因子：
6.5
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
通讯作者：
Nikolovski, Janeta
DOI：
10.1073/pnas.0401710101
发表时间：
2004-05-11
影响因子：
11.1
作者：
Claud, EC;Lu, L;Cherayil, BJ
通讯作者：
Cherayil, BJ
影响因子：
5.2
作者：
ALNAKEEB, S;THOMPSON, EN
通讯作者：
THOMPSON, EN