Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease.
Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease.
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DOI：
10.1038/s41598-022-07994-8
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发表时间：
2022-03-09
影响因子：
4.6
通讯作者：
Virmani T
中科院分区：
文献类型：
--
作者：
Syeda HB;Glover A;Pillai L;Kemp AS;Spencer H;Lotia M;Larson-Prior LJ;Virmani T
运动幅度设置在帕金森病（PD）的早期受到影响，临床表现为运动迟缓。我们的目的是确定是否上肢双手运动和双足步态的幅度设置类似调制PD。入组了27名PD和24名对照受试者。参与者进行双手反相手指敲击任务，戴着手套与关节角度传感器，和仪器步态评估。参与者进行正常和快节奏的评估，以改变运动负荷。对PD参与者进行了左旋多巴关闭（PD-OFF）和开启（PD-ON）评估。PD-OFF参与者的敲击幅度较小，并且在更多受影响的手中比对照组具有更大的敲击幅度变异性（所有p < 0.05）。在PD-OFF中，敲击幅度和步长（p = 0.030）相关。Tap振幅也与运动神经功能缺损评分（p < 0.005）、运动迟缓评分（p < 0.05）和ADL评分（p < 0.005）相关。左旋多巴对敲击幅度和步长的相对改善量是相关的。在PD中，上肢和步态幅度设置与运动需求和多巴胺补充类似地缩放。这表明这些自动化的运动功能是由共同的功能网络提供的。
Movement amplitude setting is affected early in Parkinson’s disease (PD), clinically manifesting as bradykinesia. Our objective was to determine if amplitude setting of upper limb bimanual movements and bipedal gait are similarly modulated in PD. 27 PD and 24 control participants were enrolled. Participants performed a bimanual anti-phase finger tapping task wearing gloves with joint angular sensors, and an instrumented gait assessment. Participants performed normal and fast paced assessments to vary motor load. PD participants were evaluated OFF (PD-OFF) and ON (PD-ON) levodopa. PD-OFF participants had smaller tap amplitude, and greater tap amplitude variability than controls in the more affected hands (all p < 0.05). Tap amplitude and stride length (p = 0.030) were correlated in PD-OFF. Tap amplitude was also correlated with motor UPDRS (p < 0.005) and bradykinesia motor (p < 0.05) and ADL (p < 0.005) UPDRS subscores. The relative amount of improvement in tap amplitude and stride length with levodopa was correlated. In PD, upper limb and gait amplitude setting are similarly scaled with motor demand and dopamine supplementation. This suggests these automated motor functions are subserved by common functional networks.
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影响因子：
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作者：
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通讯作者：
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