Serial Interferon-Gamma Release Assay (IGRA) Testing to Monitor Treatment Responses in Cases of Feline Mycobacteriosis.
Serial Interferon-Gamma Release Assay (IGRA) Testing to Monitor Treatment Responses in Cases of Feline Mycobacteriosis.
复制标题
DOI：
10.3390/pathogens10060657
复制
发表时间：
2021-05-26
期刊：
影响因子：
--
通讯作者：
Hope JC
中科院分区：
文献类型：
--
作者：
Mitchell JL;O'Halloran C;Stanley P;McDonald K;Burr P;Gunn-Moore DA;Hope JC
干扰素-伽马释放试验(IGRA)被用于诊断猫分枝杆菌病的病例，但使用系列检测来监测治疗反应在该物种中尚未得到评估。从接受IGRA检测以进行诊断性调查的猫种群中，识别出治疗前和治疗结束时IGRA超过对照阈值的个体。比较在IGRA治疗结束时转为阴性的猫的数量、成对抗原特异性光密度(OD)值的变化以及那些逆转的猫在治疗前抗原特异性OD值的差异。探讨了治疗后疾病复发或复发的原因。在18只猫中，4只(22%)在临床解决点转为阴性(p=0.33)，配对抗原特异性OD值没有差异(p≥0.12)，并且逆转的猫没有较低的基线OD值(p=0.63)。没有确定有统计学意义的因素来预测逆转(p≥0.08)。治疗结束时IGRA保持阳性与治疗后疾病复发无关(p=0.34)。总体而言，这些数据表明，使用IGRA监测猫的治疗反应的价值有限。
The interferon-gamma release assay (IGRA) is used to diagnose cases of feline mycobacteriosis, but the use of serial testing to monitor treatment responses has not been evaluated in this species. From a population of cats that underwent IGRA testing for diagnostic investigation, individuals were identified with a pre- and end-of-treatment IGRA that passed control thresholds. The number of cats which reverted to negative at the end-of-treatment IGRA, changes in paired antigen-specific optical density (OD) values and differences in the pre-treatment antigen-specific OD values for those which underwent reversion were compared. Factors to explain reversion or recurrence of disease post-treatment were explored. Four of 18 cats (22%) reverted to negativity at the point of clinical resolution (p = 0.33), there was no difference in paired antigen-specific OD values (p ≥ 0.12), and cats that reverted did not have a lower baseline OD value (p = 0.63). No statistically significant factors were identified to predict reversion (p ≥ 0.08). Remaining positive at the end of treatment IGRA was not associated with recurrence of disease post-treatment (p = 0.34). Overall, these data suggest there is limited value in the use of the IGRA to monitor treatment responses in cats.
登录
查看更多内容
影响因子：
9.4
作者：
Denkinger, Claudia M.;Pai, Madhukar;Menzies, Dick
通讯作者：
Menzies, Dick
影响因子：
1.7
作者：
Bennett, Alexander D.;Lalor, Stephanie;Gunn-Moore, Danielle A.
通讯作者：
Gunn-Moore, Danielle A.
影响因子：
0.3
作者：
O'Halloran, Conor;Gunn-Moore, Danielle
通讯作者：
Gunn-Moore, Danielle
影响因子：
4.3
作者：
Bosshard, Valerie;Roux-Lombard, Pascale;Janssens, Jean-Paul
通讯作者：
Janssens, Jean-Paul
影响因子：
3.1
作者：
Nenadic, Natasa;Kirin, Branka Kristic;Dodig, Slavica
通讯作者：
Dodig, Slavica