Lymphocytes and Trogocytosis-Mediated Signaling.
Lymphocytes and Trogocytosis-Mediated Signaling.
复制标题
淋巴细胞和胞裂介导的信号传导。
DOI：
10.3390/cells10061478
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发表时间：
2021-06-12
期刊：
影响因子：
6
通讯作者：
Wetzel SA
中科院分区：
文献类型：
--
作者：
Reed J;Reichelt M;Wetzel SA
胞质形成是指膜和膜相关分子在细胞间的转移。这一未被充分认识的过程已在多种生物环境中得到描述，包括神经元重塑、受精、病毒和细菌传播以及癌症，但在免疫系统细胞中得到的研究最为广泛。Trogocytosis是由多种免疫细胞类型完成的，包括嗜碱性细胞、巨噬细胞、树突状细胞、中性粒细胞、自然杀伤细胞、B细胞、γδ T细胞以及CD4+和CD8+ αβ T细胞。虽然不是内源性表达，但细胞上的穴居化分子有可能显著影响免疫反应和个体穴居化阳性细胞的生物学。许多研究都集中在噬细胞阳性细胞与其他免疫细胞相互作用和调节应答者功能的能力上。这些分子对单个单核细胞分裂阳性细胞的影响尚不清楚，但也同样重要。据报道，细胞胞化的分子包括单个细胞上受体的同源配体，如活化NK细胞配体和MHC肽。这些穴居化分子已被证明与穴居化阳性细胞上的受体相互作用并介导细胞内信号传导。在这篇综述中，我们通过聚焦自然杀伤细胞和CD4+ T淋巴细胞，讨论了这种由巨噬细胞介导的信号传导对个体巨噬细胞阳性细胞生物学的影响。
Trogocytosis is the intercellular transfer of membrane and membrane-associated molecules. This underappreciated process has been described in a variety of biological settings including neuronal remodeling, fertilization, viral and bacterial spread, and cancer, but has been most widely studied in cells of the immune system. Trogocytosis is performed by multiple immune cell types, including basophils, macrophages, dendritic cells, neutrophils, natural killer cells, B cells, γδ T cells, and CD4+ and CD8+ αβ T cells. Although not expressed endogenously, the presence of trogocytosed molecules on cells has the potential to significantly impact an immune response and the biology of the individual trogocytosis-positive cell. Many studies have focused on the ability of the trogocytosis-positive cells to interact with other immune cells and modulate the function of responders. Less understood and arguably equally important is the impact of these molecules on the individual trogocytosis-positive cell. Molecules that have been reported to be trogocytosed by cells include cognate ligands for receptors on the individual cell, such as activating NK cell ligands and MHC:peptide. These trogocytosed molecules have been shown to interact with receptors on the trogocytosis-positive cell and mediate intracellular signaling. In this review, we discuss the impact of this trogocytosis-mediated signaling on the biology of the individual trogocytosis-positive cell by focusing on natural killer cells and CD4+ T lymphocytes.
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影响因子：
32.4
作者：
Basu R;O'Quinn DB;Silberger DJ;Schoeb TR;Fouser L;Ouyang W;Hatton RD;Weaver CT
通讯作者：
Weaver CT
影响因子：
8.8
作者：
Boccasavia VL;Bovolenta ER;Villanueva A;Borroto A;Oeste CL;van Santen HM;Prieto C;Alonso-López D;Diaz-Muñoz MD;Batista FD;Alarcón B
通讯作者：
Alarcón B
影响因子：
1.5
作者：
Caumartin, Julien;LeMaoult, Joel;Carosella, Edgardo D.
通讯作者：
Carosella, Edgardo D.
影响因子：
32.4
作者：
Allenspach, EJ;Cullinan, P;Sperling, AI
通讯作者：
Sperling, AI
影响因子：
--
作者：
Alarcón B;Martínez-Martín N
通讯作者：
Martínez-Martín N