3D printing fluorescent material with tunable optical properties.
3D printing fluorescent material with tunable optical properties.
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DOI：
10.1038/s41598-021-96496-0
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发表时间：
2021-08-24
影响因子：
4.6
通讯作者：
Pogue BW
中科院分区：
文献类型：
--
作者：
Ruiz AJ;Garg S;Streeter SS;Giallorenzi MK;LaRochelle EPM;Samkoe KS;Pogue BW
荧光材料的3D打印可以帮助开发、验证和转化成像技术，包括荧光引导手术系统。尽管用于光学目标的3D打印技术取得了进展，但还没有综合的方法可以同时掺入荧光团并微调吸收和散射特性。在这里，我们介绍了一种基于光聚合物的3D打印方法，用于制造具有可调光学特性的荧光材料。结果证明了以合理的高荧光产率3D打印各种单个荧光团的能力，包括IR-125，量子点，亚甲蓝和罗丹明590。此外，在0.005-0.05 mm-1和0.2-1.5 mm-1的相关哺乳动物软组织系数范围内，分别证明了吸收和减少散射系数的调谐。荧光团掺杂的仿生和复杂几何结构的制造验证了打印特征尺寸小于200 μm的能力。所提出的方法和光学表征技术为制造固体3D打印荧光结构提供了基础，与生物医学光学直接相关，并广泛采用荧光成像中的快速制造方法。
The 3D printing of fluorescent materials could help develop, validate, and translate imaging technologies, including systems for fluorescence-guided surgery. Despite advances in 3D printing techniques for optical targets, no comprehensive method has been demonstrated for the simultaneous incorporation of fluorophores and fine-tuning of absorption and scattering properties. Here, we introduce a photopolymer-based 3D printing method for manufacturing fluorescent material with tunable optical properties. The results demonstrate the ability to 3D print various individual fluorophores at reasonably high fluorescence yields, including IR-125, quantum dots, methylene blue, and rhodamine 590. Furthermore, tuning of the absorption and reduced scattering coefficients is demonstrated within the relevant mamalian soft tissue coefficient ranges of 0.005–0.05 mm−1 and 0.2–1.5 mm−1, respectively. Fabrication of fluorophore-doped biomimicking and complex geometric structures validated the ability to print feature sizes less than 200 μm. The presented methods and optical characterization techniques provide the foundation for the manufacturing of solid 3D printed fluorescent structures, with direct relevance to biomedical optics and the broad adoption of fast manufacturing methods in fluorescence imaging.
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影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
3.5
作者：
Ruiz, Alberto J.;Wu, Mindy;Pogue, Brian W.
通讯作者：
Pogue, Brian W.
影响因子：
3.4
作者：
Dempsey LA;Persad M;Powell S;Chitnis D;Hebden JC
通讯作者：
Hebden JC
影响因子：
3.5
作者：
Gorpas, Dimitris;Koch, Maximilian;Ntziachristos, Vasilis
通讯作者：
Ntziachristos, Vasilis
影响因子：
2.2
作者：
Brackett, M. G.;Brackett, W. G.;Rueggeberg, F. A.
通讯作者：
Rueggeberg, F. A.