Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease.
Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease.
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DOI：
10.1016/j.biopsych.2011.06.019
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发表时间：
2012-05-01
影响因子：
10.6
通讯作者：
Teipel, Stefan J.
中科院分区：
文献类型：
--
作者：
Grothe, Michel;Heinsen, Helmut;Teipel, Stefan J.
关键词：
已知基底前脑胆碱能系统 (BFCS) 在正常衰老过程中会发生中度神经退行性变化，在阿尔茨海默病 (AD) 中会发生严重萎缩。然而，关于 AD 中的胆碱能病变与疾病的早期和初期阶段的关系存在争议。关于正常和病理衰老中 BFCS 结构完整性的体内成像研究仍然很少。我们将自动化形态测量技术与高维图像扭曲和 BF 胆碱能核细胞结构图相结合，应用于高分辨率 MRI 扫描的大型横截面数据集，涵盖整个成人年龄范围（20-94 岁；N=211）以及非常轻度 AD 患者（vmAD；CDR=0.5；N=69）和临床表现 AD（AD；CDR=1；N=28）。为了进行比较，我们使用自动容量测定法研究了海马体积。 BFCS 的体积从成年早期开始下降，并且在老年时萎缩加剧。 vmAD 中的体积减少在 Meynert 基底核的后部最为明显，而 AD 中的萎缩更广泛，包括整个 BFCS。在有临床表现的AD中，BFCS体积的诊断准确性达到了海马体积的诊断准确性。我们的研究结果表明，AD 中的胆碱能变性是在与年龄相关的萎缩的背景下发生的，并且 AD 中萎缩的加剧可以在认知障碍的最早阶段被检测到。 BFCS 的自动体内形态测量可能成为评估正常和病理衰老中 BF 胆碱能变性的有用工具。
The basal forebrain cholinergic system (BFCS) is known to undergo moderate neurodegenerative changes during normal aging as well as severe atrophy in Alzheimer´s disease (AD). However, there is a controversy on how the cholinergic lesion in AD relates to early and incipient stages of the disease. In-vivo imaging studies on the structural integrity of the BFCS in normal and pathological aging are still rare. We applied automated morphometry techniques in combination with high-dimensional image warping and a cytoarchitectonic map of BF cholinergic nuclei to a large cross-sectional dataset of high-resolution MRI scans, covering the whole adult age-range (20–94 years; N=211) as well as patients with very mild AD (vmAD; CDR=0.5; N=69) and clinically manifest AD (AD; CDR=1; N=28). For comparison, we investigated hippocampus volume using automated volumetry. Volume of the BFCS declined from early adulthood on and atrophy aggravated in advanced age. Volume reductions in vmAD were most pronounced in posterior parts of the nucleus basalis Meynert, while in AD atrophy was more extensive and included the whole BFCS. In clinically manifest AD, the diagnostic accuracy of BFCS volume reached the diagnostic accuracy of hippocampus volume. Our findings indicate that cholinergic degeneration in AD occurs against a background of age-related atrophy and that exacerbated atrophy in AD can be detected at earliest stages of cognitive impairment. Automated in-vivo morphometry of the BFCS may become a useful tool to assess BF cholinergic degeneration in normal and pathological aging.
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影响因子：
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作者：
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